Blood tau-PT217 contributes to the anesthesia/surgery-induced delirium-like behavior in aged mice

doi:10.1002/alz.13118

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	Blood tau-PT217 contributes to the anesthesia/surgery-induced delirium-like behavior in aged mice
	Lu, Jing 7,23; Liang, Feng 7,8,20; Bai, Ping 8,9,10; Liu, Chenghao 7,8,11; Xu, Miao 6,7,8; Sun, Zhengwang 7,8; Tian, Wenjie 3,4,5,8; Dong, Yuanlin 7,8; Zhang, Yiying 7,8; Quan, Qimin 2
刊名	ALZHEIMERS & DEMENTIA
	2023-05-30
页码	17
关键词	anesthesia delirium phosphorylated tau at threonine 217 surgery tau tau phosphorylation
ISSN号	1552-5260
DOI	10.1002/alz.13118
通讯作者	Yang, Guang(gy2268@cumc.columbia.edu) ; Xie, Zhongcong(zxie@mgh.harvard.edu)
英文摘要	INTRODUCTIONBlood phosphorylated tau at threonine 217 (tau-PT217) is a newly established biomarker for Alzheimer's disease and postoperative delirium in patients. However, the mechanisms and consequences of acute changes in blood tau-PT217 remain largely unknown. METHODSWe investigated the effects of anesthesia/surgery on blood tau-PT217 in aged mice, and evaluated the associated changes in B cell populations, neuronal excitability in anterior cingulate cortex, and delirium-like behavior using positron emission tomography imaging, nanoneedle technology, flow cytometry, electrophysiology, and behavioral tests. RESULTSAnesthesia/surgery induced acute increases in blood tau-PT217 via enhanced generation in the lungs and release from B cells. Tau-PT217 might cross the blood-brain barrier, increasing neuronal excitability and inducing delirium-like behavior. B cell transfer and WS635, a mitochondrial function enhancer, mitigated the anesthesia/surgery-induced changes. DISCUSSIONAcute increases in blood tau-PT217 may contribute to brain dysfunction and postoperative delirium. Targeting B cells or mitochondrial function may have therapeutic potential for preventing or treating these conditions.
资助项目	National Institutes of Health[AG062509] ; National Institutes of Health[AG070761] ; National Institutes of Health[AG051812] ; [AG041274]
WOS关键词	ALZHEIMERS-DISEASE ; PERMEABILITY TRANSITION ; POSTOPERATIVE DELIRIUM ; COGNITIVE DYSFUNCTION ; RISK-FACTORS ; TAU ; REDUCTION ; DEMENTIA ; DEFICITS ; CYCLOSPORINE
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	WILEY
WOS记录号	WOS:000997439800001
资助机构	National Institutes of Health
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/53326]
专题	数字内容技术与服务研究中心_听觉模型与认知计算
通讯作者	Yang, Guang; Xie, Zhongcong
作者单位	1.Beth Israel Deaconess Med Ctr, Dept Med, Div Gen Med & Primary Care, Boston, MA USA 2.NanoMosaic Inc, Woburn, MA USA 3.Massachusetts Gen Hosp, Dept Med, Cardiol Div, Charlestown, MA USA 4.Massachusetts Gen Hosp, Cardiovasc Res Ctr, Dept Med, Charlestown, MA USA 5.Sichuan Acad Med Sci & Sichuan Prov Peoples Hosp, Dept Cardiol, Chengdu, Peoples R China 6.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Anesthesiol, Guangzhou, Peoples R China 7.Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, Geriatr Anesthesia Res Unit, Charlestown, MA USA 8.Harvard Med Sch, Charlestown, MA USA 9.Sichuan Univ, West China Hosp, Precis Med Key Lab Sichuan Prov, Targeted Tracer Res & Dev Lab, Chengdu, Peoples R China 10.Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Dept Radiol, Charlestown, MA USA
推荐引用方式 GB/T 7714	Lu, Jing,Liang, Feng,Bai, Ping,et al. Blood tau-PT217 contributes to the anesthesia/surgery-induced delirium-like behavior in aged mice[J]. ALZHEIMERS & DEMENTIA,2023:17.
APA	Lu, Jing.,Liang, Feng.,Bai, Ping.,Liu, Chenghao.,Xu, Miao.,...&Xie, Zhongcong.(2023).Blood tau-PT217 contributes to the anesthesia/surgery-induced delirium-like behavior in aged mice.ALZHEIMERS & DEMENTIA,17.
MLA	Lu, Jing,et al."Blood tau-PT217 contributes to the anesthesia/surgery-induced delirium-like behavior in aged mice".ALZHEIMERS & DEMENTIA (2023):17.