2-Methoxyestradiol loaded mesoporous polydopamine nanoprobes for hypoxia alleviation and sorafenib synergistic treatment of hepatocellular carcinoma

doi:10.1016/j.matdes.2023.112137

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	2-Methoxyestradiol loaded mesoporous polydopamine nanoprobes for hypoxia alleviation and sorafenib synergistic treatment of hepatocellular carcinoma
	Wang, Peifeng 2,4,7; Du, Yang 1,2; Zhao, Xingyang 4,7; Hu, Yueyang 4,7; Zhou, Tianjun 5; Liang, Xiaolong 3; Fang, Chihua 4,7; Tian, Jie 2,6
刊名	MATERIALS & DESIGN
	2023-08-01
卷号	232 页码:11
关键词	Hepatocellular carcinoma Mesoporous polydopamine Photothermal therapy Sorafenib Hypoxia
ISSN号	0264-1275
DOI	10.1016/j.matdes.2023.112137
通讯作者	Liang, Xiaolong(xiaolong_liang@bjmu.edu.cn) ; Fang, Chihua(fangchihua@smu.edu.cn) ; Tian, Jie()
英文摘要	Hepatocellular carcinoma is a common and highly malignant disease. As a currently designated systemic chemotherapeutic agent for advanced Hepatocellular carcinoma, sorafenib has been confronted with dilemma of drug-resistance caused by tumor hypoxia, which hinders the therapeutic efficacy of the drug. Based on this, amultifunctional mesoporous polydopamine nanoprobe 2Me-SPIO-CY5.5@AAZ-MPDA with a mesoporous frame loaded 2-Methoxyestradiol, Superparamagnetic Iron Oxide Nanoparticles and the near-infrared dye cyanine 5.5, conjugated with hypoxia Hepatocellular carcinoma-specific targeting molecule of sulfonamides acetazolamide, is fabricated for hypoxic region targeting, sorafenib resistance reversion and photothermal therapy of Hepatocellular carcinoma. In addition, the magnetic resonance imaging/fluorescence/photoacoustic tri-modal imaging ability enables the tracing of the nanoprobes and monitoring the treatment procedure in vivo, providing a new methods of imaging-guided Hepatocellular carcinoma synergic treatment which improves the long-term therapeutic effects of sorafenib. (c) 2023 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
资助项目	National Natural Science Founda- tion of China[81627805] ; National Natural Science Founda- tion of China[12026602] ; National Key Research and Development Program of China[2016YFC0106500]
WOS关键词	TUMOR ; ANGIOGENESIS ; IX
WOS研究方向	Materials Science
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:001038724000001
资助机构	National Natural Science Founda- tion of China ; National Key Research and Development Program of China
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/53909]
专题	自动化研究所_中国科学院分子影像重点实验室
通讯作者	Liang, Xiaolong; Fang, Chihua; Tian, Jie
作者单位	1.Univ Chinese Acad Sci, Beijing 100080, Peoples R China 2.Chinese Acad Sci Inst Automat, CAS Key Lab Mol Imaging, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China 3.Peking Univ Third Hosp, Dept Ultrasound, Beijing 100191, Peoples R China 4.Southern Med Univ, Zhujiang Hosp, Dept Hepatobiliary Surg, Guangzhou 510280, Peoples R China 5.Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Dept Thorac Surg, Guangzhou, Peoples R China 6.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Beijing 100191, Peoples R China 7.Prov Clin & Engn Ctr Digital Med, Guangzhou 510280, Peoples R China
推荐引用方式 GB/T 7714	Wang, Peifeng,Du, Yang,Zhao, Xingyang,et al. 2-Methoxyestradiol loaded mesoporous polydopamine nanoprobes for hypoxia alleviation and sorafenib synergistic treatment of hepatocellular carcinoma[J]. MATERIALS & DESIGN,2023,232:11.
APA	Wang, Peifeng.,Du, Yang.,Zhao, Xingyang.,Hu, Yueyang.,Zhou, Tianjun.,...&Tian, Jie.(2023).2-Methoxyestradiol loaded mesoporous polydopamine nanoprobes for hypoxia alleviation and sorafenib synergistic treatment of hepatocellular carcinoma.MATERIALS & DESIGN,232,11.
MLA	Wang, Peifeng,et al."2-Methoxyestradiol loaded mesoporous polydopamine nanoprobes for hypoxia alleviation and sorafenib synergistic treatment of hepatocellular carcinoma".MATERIALS & DESIGN 232(2023):11.