Molecular imaging-guided extracellular vesicle-based drug delivery for precise cancer management: Current status and future perspectives

doi:10.1016/j.jconrel.2023.08.040

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	Molecular imaging-guided extracellular vesicle-based drug delivery for precise cancer management: Current status and future perspectives
	Cheng, Zhongquan 2,3; Shang, Jihuan 4; Wang, Huarong 2; Yu, Leyi 5; Yuan, Zhu 2,12; Zhang, Yinlong 7,11; Du, Yang 1,3,8; Tian, Jie 3,6,9,10
刊名	JOURNAL OF CONTROLLED RELEASE
	2023-10-01
卷号	362 页码:97-120
关键词	Extracellular vesicles Molecular imaging Cancer Diagnosis Therapy
ISSN号	0168-3659
DOI	10.1016/j.jconrel.2023.08.040
通讯作者	Yuan, Zhu(BJFH_yz_paper@163.com) ; Zhang, Yinlong(zhangyl@nanoctr.cn) ; Du, Yang(yang.du@ia.ac.cn) ; Tian, Jie(tian@ieee.org)
英文摘要	Extracellular vesicles (EVs), the mediators of intercellular communication, have attracted the attention of researchers for the important roles they play in cancer treatment. Compared with other inorganic nano-materials, EVs possess the advantages of higher biocompatibility, better physiochemical stability, easier surface modification, and excellent biosafety. They can be used as an advanced drug delivery system with an improved therapeutic index for various therapeutic agents. Engineered EV-based imaging and therapeutic agents (engineered EVs) have emerged as useful tools in targeted cancer diagnosis and therapy. Non-invasive tracing of engineered EVs contributes to a better evaluation of their functions in cancer progression, in vivo dynamic biodistribution, therapeutic response, and drug-loading efficiency. Recent advances in real-time molecular imaging (MI), and innovative EV labeling strategies have led to the development of novel tools that can evaluate the pharmacokinetics of engineered EVs in cancer management, which may accelerate further clinical translation of novel EV-based drug delivery platforms. Herein, we review the latest advances in EVs, their characteristics, and current examples of EV-based targeted drug delivery for cancer. Then, we discuss the prominent applications of MI for tracing both natural and engineered EVs. Finally, we discuss the current challenges and considerations of EVs in targeted cancer treatment and the limitations of different MI modalities. In the coming decades, EV-based
资助项目	National Natural Science Foundation of China[82272111] ; National Natural Science Foundation of China[62027901,92159303] ; National Natural Science Foundation of China[81871514] ; Beijing Natural Science Foundation[7212207]
WOS关键词	EXOSOME-MEDIATED DELIVERY ; STEM-CELLS ; ENGINEERED EXOSOMES ; COLON-CANCER ; BIODISTRIBUTION ; NANOPARTICLES ; STRATEGIES ; THERAPY ; SYSTEM ; MICROVESICLES
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:001075462300001
资助机构	National Natural Science Foundation of China ; Beijing Natural Science Foundation
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/53143]
专题	自动化研究所_中国科学院分子影像重点实验室
通讯作者	Yuan, Zhu; Zhang, Yinlong; Du, Yang; Tian, Jie
作者单位	1.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China 2.Capital Med Univ, Beijing Friendship Hosp, Dept Gen Surg, Beijing 100050, Peoples R China 3.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China 4.Nanjing Med Univ, Sch Clin Med, Nanjing 211166, Peoples R China 5.Beijing Haidian Hosp, Beijing 100080, Peoples R China 6.Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Med, Beijing, Peoples R China 7.Univ Chinese Acad Sci, Sch Nanosci & Engn, Beijing 100049, Peoples R China 8.Univ Chinese Acad Sci, Beijing 100080, Peoples R China 9.Beihang Univ, Sci & Engn, Beijing 100191, Peoples R China 10.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med Sci & Engn, Beijing 100191, Peoples R China
推荐引用方式 GB/T 7714	Cheng, Zhongquan,Shang, Jihuan,Wang, Huarong,et al. Molecular imaging-guided extracellular vesicle-based drug delivery for precise cancer management: Current status and future perspectives[J]. JOURNAL OF CONTROLLED RELEASE,2023,362:97-120.
APA	Cheng, Zhongquan.,Shang, Jihuan.,Wang, Huarong.,Yu, Leyi.,Yuan, Zhu.,...&Tian, Jie.(2023).Molecular imaging-guided extracellular vesicle-based drug delivery for precise cancer management: Current status and future perspectives.JOURNAL OF CONTROLLED RELEASE,362,97-120.
MLA	Cheng, Zhongquan,et al."Molecular imaging-guided extracellular vesicle-based drug delivery for precise cancer management: Current status and future perspectives".JOURNAL OF CONTROLLED RELEASE 362(2023):97-120.