Rapid method for accurate peak position extraction in high-field asymmetric ion mobility spectrometry | |
Hu, Jun1,2; Liu, Youjiang1; Liu, Shaomin1; Li, Shan1; Wang, Han1,2; Chen, Chilai1 | |
刊名 | CHINESE JOURNAL OF ANALYTICAL CHEMISTRY |
2023-10-01 | |
卷号 | 51 |
关键词 | High-field asymmetric ion mobility spectrometry Scan speed Peak position Nonlinear function |
ISSN号 | 0253-3820 |
DOI | 10.1016/j.cjac.2023.100305 |
通讯作者 | Chen, Chilai(chlchen@iim.ac.cn) |
英文摘要 | High-field asymmetric waveform ion mobility spectrometry (FAIMS) enables precise identification of substances through fingerprint spectra obtained by multi-cycle scans at different separation voltages (DV) and nonlinear functions. To improve the scan speed of compensating voltage (CV) in multi-cycle scanning, the challenge arises in peak position shifts. This article proposes a method to accurately determine peak positions regardless of scan speed by exploiting the symmetric features of spectra obtained through positive and negative CV scans. The proposed method enables extremely fast scan speeds. A custom-built FAIMS system was used to verify the correlation between peak shifts and scan speed, the symmetry of spectra peaks under positive and negative CV scan modes, and the peak positions and solution errors of nonlinear functions by using benzene, styrene, acetone, toluene, m-xylene, and hydrogen sulfide as experimental samples. The results demonstrate the widespread occurrence of peak shifts, with peak deviations reaching as high as 2.49% even in slow scans of 0.75 V/s. As scan speed increases, peak position deviations gradually increase, with the maximum deviation reaching 46.83% at a scan speed of 30 V/s. By applying the proposed averaging method, peak positions of the six substances were obtained within the scan speed range of 30 to 0.75 V/s. Compared to traditional methods, the maximum peak position error using the averaging method was reduced by approximately 87.5%, and the spectrum acquisition time was reduced by 85%. The use of the averaging method reduced the calculation error of the alpha function by 88% and decreased the acquisition time by 80%. The research findings of this study offer a solution for the accurate determination of peak positions in FAIMS under fast scanning. |
资助项目 | Strategic Priority Research Program of Chinese Academy of Sciences Deepsea and Hadal Intelligent Technology and Seafloor Science Laboratory[XDA22020503] ; National Natural Science Foundation of China[61871367] |
WOS关键词 | DISTORTION ; TIME |
WOS研究方向 | Chemistry |
语种 | 英语 |
出版者 | SCIENCE PRESS |
WOS记录号 | WOS:001081424900001 |
资助机构 | Strategic Priority Research Program of Chinese Academy of Sciences Deepsea and Hadal Intelligent Technology and Seafloor Science Laboratory ; National Natural Science Foundation of China |
内容类型 | 期刊论文 |
源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/133475] |
专题 | 中国科学院合肥物质科学研究院 |
通讯作者 | Chen, Chilai |
作者单位 | 1.Chinese Acad Sci, Hefei Inst Phys Sci, Hefei 230031, Peoples R China 2.Univ Sci & Technol China, Hefei 230026, Peoples R China |
推荐引用方式 GB/T 7714 | Hu, Jun,Liu, Youjiang,Liu, Shaomin,et al. Rapid method for accurate peak position extraction in high-field asymmetric ion mobility spectrometry[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2023,51. |
APA | Hu, Jun,Liu, Youjiang,Liu, Shaomin,Li, Shan,Wang, Han,&Chen, Chilai.(2023).Rapid method for accurate peak position extraction in high-field asymmetric ion mobility spectrometry.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,51. |
MLA | Hu, Jun,et al."Rapid method for accurate peak position extraction in high-field asymmetric ion mobility spectrometry".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 51(2023). |
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