Repeated Low-Level Red Light Therapy for the Control of Myopia in Children: A Meta-Analysis of Randomized Controlled Trials

doi:10.1097/ICL.0000000000001020

	Repeated Low-Level Red Light Therapy for the Control of Myopia in Children: A Meta-Analysis of Randomized Controlled Trials
	Wang, Fei 3; Peng, Wei 2; Jiang, Zhengxuan 1,3
刊名	EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
	2023-10-01
卷号	49
关键词	Repeated low-level red light Myopia Axial length Cycloplegic spherical equivalent refraction Meta-analysis
ISSN号	1542-2321
DOI	10.1097/ICL.0000000000001020
通讯作者	Jiang, Zhengxuan(zx_jiang9533@163.com)
英文摘要	Background: Repeated low-level red light (RLRL) therapy has been suggested to be effective in children with myopia. However, evidence from randomized controlled trials (RCTs) is still limited. We performed a meta-analysis of RCTs to systematically evaluate the efficacy of RLRL on changes of axial length (AL) and cycloplegic spherical equivalent refraction (SER) in children with myopia. Methods: Relevant RCTs were obtained through a search of electronic databases including PubMed, Embase, Cochrane Library, Wanfang, and China National Knowledge Infrastructure from inception to September 15, 2022. A random-effects model was used to pool the results after incorporating the influence of potential heterogeneity. Subgroup analyses were performed according to the control treatment and follow-up duration. Results: A total of seven RCTs involving 1,031 children with myopia, aged 6 to 16 years, were included in the meta-analysis. Compared with control treatment without RLRL, treatment with RLRL was associated with a significantly reduced AL (mean difference [MD]: -0.25 mm, 95% confidence interval [CI]: -0.32 to -0.17, P,<0.001; I-2=13%) and a significantly increased cycloplegic SER (MD: 0.60 D, 95% CI: 0.44-0.76, P,<0.001; I-2=20%). Further subgroup analyses showed consistent results in studies comparing children wearing single vision lenses and those receiving active treatment including orthokeratology or low-dose atropine eye drops, as well as studies of treatment duration of 6 and 12 months. Conclusions: Results of the meta-analysis suggested that RLRL treatment is effective for slowing down the progression of myopia in children aged 6 to 16 years.
WOS关键词	AXIAL ELONGATION ; EFFICACY ; PROGRESSION
WOS研究方向	Ophthalmology
语种	英语
出版者	LIPPINCOTT WILLIAMS & WILKINS
WOS记录号	WOS:001073492400006
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/133463]
专题	中国科学院合肥物质科学研究院
通讯作者	Jiang, Zhengxuan
作者单位	1.Anhui Med Univ, Hosp 2, Dept Ophthalmol, 678 Furong Rd,Econ & Technol Dev Zone, Hefei 230000, Peoples R China 2.Chinese Acad Sci, Hefei Inst Phys Sci, Hefei, Peoples R China 3.Anhui Med Univ, Hosp 2, Dept Ophthalmol, Hefei, Peoples R China
推荐引用方式 GB/T 7714	Wang, Fei,Peng, Wei,Jiang, Zhengxuan. Repeated Low-Level Red Light Therapy for the Control of Myopia in Children: A Meta-Analysis of Randomized Controlled Trials[J]. EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE,2023,49.
APA	Wang, Fei,Peng, Wei,&Jiang, Zhengxuan.(2023).Repeated Low-Level Red Light Therapy for the Control of Myopia in Children: A Meta-Analysis of Randomized Controlled Trials.EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE,49.
MLA	Wang, Fei,et al."Repeated Low-Level Red Light Therapy for the Control of Myopia in Children: A Meta-Analysis of Randomized Controlled Trials".EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE 49(2023).