'Passive' nanoparticles for organ-selective systemic delivery: design, mechanism and perspective

doi:10.1039/d2cs00998

	'Passive' nanoparticles for organ-selective systemic delivery: design, mechanism and perspective
	Fu, Liyi 2,3,4; Zhang, Yang 2,3; Farokhzad, Ryan A.2,3; Mendes, Barbara B.1; Conde, Joao 1; Shi, Jinjun 2,3
刊名	CHEMICAL SOCIETY REVIEWS
	2023-10-11
ISSN号	0306-0012
DOI	10.1039/d2cs00998
通讯作者	Shi, Jinjun()
英文摘要	Nanotechnology has shown tremendous success in the drug delivery field for more effective and safer therapy, and has recently enabled the clinical approval of RNA medicine, a new class of therapeutics. Various nanoparticle strategies have been developed to improve the systemic delivery of therapeutics, among which surface modification of targeting ligands on nanoparticles has been widely explored for 'active' delivery to a specific organ or diseased tissue. Meanwhile, compelling evidence has recently been reported that organ-selective targeting may also be achievable by systemic administration of nanoparticles without surface ligand modification. In this Review, we highlight this unique set of 'passive' nanoparticles and their compositions and mechanisms for organ-selective delivery. In particular, the lipid-based, polymer-based, and biomimetic nanoparticles with tropism to different specific organs after intravenous administration are summarized. The underlying mechanisms (e.g., protein corona and size effect) of these nanosystems for organ selectivity are also extensively discussed. We further provide perspectives on the opportunities and challenges in this exciting area of organ-selective systemic nanoparticle delivery. This review article highlights a unique set of 'passive' nanoparticles for organ-selective systemic delivery and discusses the underlying biological mechanisms.
资助项目	J. S. acknowledges the support from the National Institutes of Health grants R01CA200900, R01HL156362, R01HL158097, R01HL159012, R01HL162367, and R33HL168751, and the Innovation Discovery Grants award from the Mass General Brigham. The content is solely th[R01CA200900] ; J. S. acknowledges the support from the National Institutes of Health grants R01CA200900, R01HL156362, R01HL158097, R01HL159012, R01HL162367, and R33HL168751, and the Innovation Discovery Grants award from the Mass General Brigham. The content is solely th[R01HL156362] ; J. S. acknowledges the support from the National Institutes of Health grants R01CA200900, R01HL156362, R01HL158097, R01HL159012, R01HL162367, and R33HL168751, and the Innovation Discovery Grants award from the Mass General Brigham. The content is solely th[R01HL158097] ; J. S. acknowledges the support from the National Institutes of Health grants R01CA200900, R01HL156362, R01HL158097, R01HL159012, R01HL162367, and R33HL168751, and the Innovation Discovery Grants award from the Mass General Brigham. The content is solely th[R01HL159012] ; J. S. acknowledges the support from the National Institutes of Health grants R01CA200900, R01HL156362, R01HL158097, R01HL159012, R01HL162367, and R33HL168751, and the Innovation Discovery Grants award from the Mass General Brigham. The content is solely th[R01HL162367] ; J. S. acknowledges the support from the National Institutes of Health grants R01CA200900, R01HL156362, R01HL158097, R01HL159012, R01HL162367, and R33HL168751, and the Innovation Discovery Grants award from the Mass General Brigham. The content is solely th[R33HL168751] ; National Institutes of Health[848325] ; European Research Council - ERC
WOS关键词	MESSENGER-RNA DELIVERY ; PROTEIN CORONA ; LIPID NANOPARTICLES ; TARGETED DELIVERY ; DRUG-DELIVERY ; MESOSCALE NANOPARTICLES ; LUNG ENDOTHELIUM ; SIRNA DELIVERY ; LIVER ; ADSORPTION
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:001078874400001
资助机构	J. S. acknowledges the support from the National Institutes of Health grants R01CA200900, R01HL156362, R01HL158097, R01HL159012, R01HL162367, and R33HL168751, and the Innovation Discovery Grants award from the Mass General Brigham. The content is solely th ; National Institutes of Health ; European Research Council - ERC
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/133435]
专题	中国科学院合肥物质科学研究院
通讯作者	Shi, Jinjun
作者单位	1.Univ Nova Lisboa, Fac Ciencias Med, NOVA Med Sch, ToxOm,NMS FCM, Lisbon, Portugal 2.Harvard Med Sch, Brigham & Womens Hosp, Dept Anesthesiol Perioperat & Pain Med, Boston, MA 02115 USA 3.Harvard Med Sch, Brigham & Womens Hosp, Ctr Nanomed, Boston, MA 02115 USA 4.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Hlth & Med Technol, Hefei 230031, Anhui, Peoples R China
推荐引用方式 GB/T 7714	Fu, Liyi,Zhang, Yang,Farokhzad, Ryan A.,et al. 'Passive' nanoparticles for organ-selective systemic delivery: design, mechanism and perspective[J]. CHEMICAL SOCIETY REVIEWS,2023.
APA	Fu, Liyi,Zhang, Yang,Farokhzad, Ryan A.,Mendes, Barbara B.,Conde, Joao,&Shi, Jinjun.(2023).'Passive' nanoparticles for organ-selective systemic delivery: design, mechanism and perspective.CHEMICAL SOCIETY REVIEWS.
MLA	Fu, Liyi,et al."'Passive' nanoparticles for organ-selective systemic delivery: design, mechanism and perspective".CHEMICAL SOCIETY REVIEWS (2023).