Monomeric compounds from traditional Chinese medicine: New hopes for drug discovery in pulmonary fibrosis

doi:10.1016/j.biopha.2023.114226

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 海岸带生物学与生物资源利用重点实验室

	Monomeric compounds from traditional Chinese medicine: New hopes for drug discovery in pulmonary fibrosis
	Wang, Qi 2,3; Li, Wenjun 2,3; Hu, Haibo 1; Lu, Xuechao 1; Qin, Song 2,3
刊名	BIOMEDICINE & PHARMACOTHERAPY
	2023-03-01
卷号	159 页码:16
关键词	Pulmonary fibrosis Monomeric compounds Flavonoids Alkaloid Terpenoids Phenols Saponins Quinones
ISSN号	0753-3322
DOI	10.1016/j.biopha.2023.114226
通讯作者	Lu, Xuechao(hospitalbreathing@163.com) ; Qin, Song(sqin@yic.ac.cn)
英文摘要	Pulmonary fibrosis (PF) is a chronic and irreversible pulmonary disease, and can lead to decreased lung function, respiratory failure and even death. The pathogenesis research and treatment strategy of PF significantly lag behind the medical progress and clinical needs. The treatment of this disease remains a thorny clinical problem, and the effective therapeutic drugs are still limited. Monomeric compounds from traditional Chinese medicine own various biological activities and high safety. They play a broad part in treating diseases and is also a candidate drug for preventing and treating PF. In this paper, we reviewed the mechanism of action and potential value of various anti-PF monomeric compounds from traditional Chinese medicine. These monomeric com-pounds can attenuate inflammatory response, oxidative stress, epithelial mesenchymal transformation and other processes of lung through many signaling pathways, and inhibit the activation and differentiation of fibroblasts, thus contributing to the treatment of PF. This review can provide new ideas for the development of anti-PF drugs in high efficiency with low toxicity.
WOS关键词	NITRIC-OXIDE SYNTHASE ; INDUCED LUNG FIBROSIS ; INFLAMMATORY RESPONSE ; KAPPA-B ; INJURY ; ACTIVATION ; INHIBITION ; FIBROBLAST ; OXYMATRINE ; MICE
WOS研究方向	Research & Experimental Medicine ; Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000991197600001
资助机构	National Key Research and Devel-opment Program ; Qingdao Scientific Research Project of TCM ; Shandong Science and Technology Development Project of TCM ; Qingdao Guidance Plan of Medical Science
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/32926]
专题	海岸带生物学与生物资源利用重点实验室
通讯作者	Lu, Xuechao; Qin, Song
作者单位	1.Qingdao Hiser Hosp, Qingdao Hosp Tradit Chinese Med, Qingdao 266033, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 3.Shandong Univ Tradit Chinese Med, Jinan 250355, Peoples R China
推荐引用方式 GB/T 7714	Wang, Qi,Li, Wenjun,Hu, Haibo,et al. Monomeric compounds from traditional Chinese medicine: New hopes for drug discovery in pulmonary fibrosis[J]. BIOMEDICINE & PHARMACOTHERAPY,2023,159:16.
APA	Wang, Qi,Li, Wenjun,Hu, Haibo,Lu, Xuechao,&Qin, Song.(2023).Monomeric compounds from traditional Chinese medicine: New hopes for drug discovery in pulmonary fibrosis.BIOMEDICINE & PHARMACOTHERAPY,159,16.
MLA	Wang, Qi,et al."Monomeric compounds from traditional Chinese medicine: New hopes for drug discovery in pulmonary fibrosis".BIOMEDICINE & PHARMACOTHERAPY 159(2023):16.