Real-Time Monitoring of a Single Molecule in Sub-nanometer Space by Dynamic Surface-Enhanced Raman Spectroscopy

doi:10.1021/acs.jpclett.3c02276

	Real-Time Monitoring of a Single Molecule in Sub-nanometer Space by Dynamic Surface-Enhanced Raman Spectroscopy
	Yan, Wuwen 3,4; Chen, Siyu 3,4; Li, Pan 2,4; Dong, Ronglu 2,4; Shin, Hyun-Hang 1; Yang, Liangbao 2,3,4
刊名	JOURNAL OF PHYSICAL CHEMISTRY LETTERS
	2023-09-22
卷号	14
ISSN号	1948-7185
DOI	10.1021/acs.jpclett.3c02276
通讯作者	Shin, Hyun-Hang(sunabc86@snu.ac.kr) ; Yang, Liangbao(lbyang@iim.ac.cn)
英文摘要	In biology and chemistry, the ultimate goal is to monitor single molecules without labels. However, long-term monitoring of label-free molecules remains a challenge. Here, on the basis of the photothermal effect of gold nanorods (GNRs), we developed a platform for monitoring of a single molecule employing surface-enhanced Raman spectroscopy (SERS). Laser re-irradiation forms 1.0 nm gaps between GNRs, allowing us to observe single crystal violet (CV) molecules blinking for up to 4 min with dynamic surface-enhanced Raman spectroscopy (D-SERS). Bianalyte experiments confirm single-molecule features at CV concentrations of 10(-14) M. Combining density functional theory (DFT) calculations with a free CV molecule observed in millisecond D-SERS, we propose that CV molecules can be confined to sub-nanometer space and the orientation of an individual CV moving in the range of 50-90(degrees) can be dynamically captured by D-SERS. This will provide a novel idea for effective exploration of the temporal and spatial dynamic processes of different reactions.
资助项目	National Natural Science Foundation of China[52232007] ; Anhui Provincial Natural Science Foundation Project[2208085MB31] ; Hefei Institutes of Physical Science (HFIPS) Director's Fund[YZJJQY202201]
WOS关键词	SERS ACTIVATED PLATFORM ; SCATTERING ; NANOPARTICLES ; DFT
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:001075608200001
资助机构	National Natural Science Foundation of China ; Anhui Provincial Natural Science Foundation Project ; Hefei Institutes of Physical Science (HFIPS) Director's Fund
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/132564]
专题	中国科学院合肥物质科学研究院
通讯作者	Shin, Hyun-Hang; Yang, Liangbao
作者单位	1.Seoul Natl Univ, Dept Chem, Seoul 08826, South Korea 2.Chinese Acad Sci, Hefei Canc Hosp, Dept Pharm, Hefei 230031, Anhui, Peoples R China 3.Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China 4.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Hlth & Med Technol, Hefei 230031, Anhui, Peoples R China
推荐引用方式 GB/T 7714	Yan, Wuwen,Chen, Siyu,Li, Pan,et al. Real-Time Monitoring of a Single Molecule in Sub-nanometer Space by Dynamic Surface-Enhanced Raman Spectroscopy[J]. JOURNAL OF PHYSICAL CHEMISTRY LETTERS,2023,14.
APA	Yan, Wuwen,Chen, Siyu,Li, Pan,Dong, Ronglu,Shin, Hyun-Hang,&Yang, Liangbao.(2023).Real-Time Monitoring of a Single Molecule in Sub-nanometer Space by Dynamic Surface-Enhanced Raman Spectroscopy.JOURNAL OF PHYSICAL CHEMISTRY LETTERS,14.
MLA	Yan, Wuwen,et al."Real-Time Monitoring of a Single Molecule in Sub-nanometer Space by Dynamic Surface-Enhanced Raman Spectroscopy".JOURNAL OF PHYSICAL CHEMISTRY LETTERS 14(2023).