Chiral Recognition of D/L-Ribose by Visual and SERS Assessments

doi:10.3390/molecules28186480

	Chiral Recognition of D/L-Ribose by Visual and SERS Assessments
	Yao, Guohua 1,2; Liu, Chao 1; Elsherbiny, Shereen M.1; Huang, Qing 1
刊名	MOLECULES
	2023-09-01
卷号	28
关键词	ribose chiral recognition visual sensor colorimetry SERS
DOI	10.3390/molecules28186480
通讯作者	Huang, Qing(huangq@ipp.ac.cn)
英文摘要	Ribose is the central molecular unit in ribose nucleic acid (RNA). Ribose is a key molecule in the study of many persistent scientific mysteries, such as the origin of life and the chiral homogeneity of biological molecules. Therefore, the chiral recognition of ribose is of great significance. The traditional method of chiral recognition of ribose is HPLC, which is time-consuming, expensive, and can only be operated in the laboratory. There is no report on optical analytical techniques that can quickly detect the chirality of ribose. In this study, a simple and convenient approach for the chiral recognition of ribose has been developed. beta-cyclodextrin(beta-CD)-coated Ag NPs aggregate after adding D-ribose, so that D-/L-ribose can be identified using visual colorimetry and/or surface-enhanced Raman spectroscopy (SERS). The color change visible to the naked eye can readily distinguish the chirality of ribose, while the SERS method can provide the more sensitive analysis of enantiomeric ribose. The advantages of this method are that it is fast, convenient, low cost, and can be operated outside the laboratory. DFT calculations show that D-ribose and cyclodextrin have the same chirality, forming multiple strong hydrogen bonds between them; thus, D/L-ribose will induce different optical effects.
资助项目	National Natural Science Foundation of China[11635013] ; National Natural Science Foundation of China[21904127] ; National Key R&D Program of China[2022YFA1503504] ; Anhui Provincial Natural Science Foundation[1908085MB53]
WOS关键词	DENSITY FUNCTIONALS ; NONCOVALENT INTERACTIONS ; CRYSTAL-STRUCTURE ; ORIGIN ; PERFORMANCE ; ADSORPTION ; M06-2X ; SENSOR ; SUGARS ; DFT
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	MDPI
WOS记录号	WOS:001077878700001
资助机构	National Natural Science Foundation of China ; National Key R&D Program of China ; Anhui Provincial Natural Science Foundation
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/132504]
专题	中国科学院合肥物质科学研究院
通讯作者	Huang, Qing
作者单位	1.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Intelligent Machines, CAS Key Lab Ion Beam Bioengn, Hefei 230031, Peoples R China 2.Shanghai Normal Univ, Joint Int Res Lab Resource Chem, Educ Minist Key Lab Resource Chem, Minist Educ,Shanghai Noncarbon Energy Convers & Ut, Shanghai 200234, Peoples R China
推荐引用方式 GB/T 7714	Yao, Guohua,Liu, Chao,Elsherbiny, Shereen M.,et al. Chiral Recognition of D/L-Ribose by Visual and SERS Assessments[J]. MOLECULES,2023,28.
APA	Yao, Guohua,Liu, Chao,Elsherbiny, Shereen M.,&Huang, Qing.(2023).Chiral Recognition of D/L-Ribose by Visual and SERS Assessments.MOLECULES,28.
MLA	Yao, Guohua,et al."Chiral Recognition of D/L-Ribose by Visual and SERS Assessments".MOLECULES 28(2023).