Gradient-Based Pulsed Excitation and Relaxation Encoding in Magnetic Particle Imaging

doi:10.1109/TMI.2022.3193219

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	Gradient-Based Pulsed Excitation and Relaxation Encoding in Magnetic Particle Imaging
	Jia, Guang 11; Huang, Liyu 10; Wang, Ze 11; Liang, Xiaofeng 11; Zhang, Yu 11; Zhang, Yifei 11; Miao, Qiguang 11; Hu, Kai 9; Li, Tanping 9; Wang, Ying 8
刊名	IEEE TRANSACTIONS ON MEDICAL IMAGING
	2022-12-01
卷号	41 期号:12 页码:3725-3733
关键词	Magnetic particle imaging pulsed excitation gradient field field free line spatial encoding tomography magnetic nanoparticles Debye relaxation time system matrix singular value decomposition
ISSN号	0278-0062
DOI	10.1109/TMI.2022.3193219
通讯作者	Jia, Guang(gjia@xidian.edu.cn) ; Li, Tanping(tpli@xidian.edu.cn) ; Tian, Jie(tian@ieee.org)
英文摘要	Magnetic particle imaging (MPI) is a radiationfree vessel- and target-imaging modality that can sensitively detect nanoparticles. A static magnetic gradient field, referred to as a selection field, is required in MPI to provide a field-free region (FFR) for spatial encoding. The image resolution of MPI is closely related to the size of the FFR, which is determined by the selection field gradient amplitude. Because of the limitations of existing gradient coil hardware, the image resolution of MPI cannot satisfy the clinical requirements of human in vivo imaging. Pulsed excitation has been confirmed to improve the image resolution of MPI by breaking down the `relaxation wall.' This work proposes the use of a pulsed waveform magnetic gradient from magnetic resonance imaging to further improve the image resolution of MPI. Through alignment of the gradient direction along the field-free line (FFL), each location on the FFL is able to have a unique excitation field strength that generates a specific relaxation-induced decay signal. Through excitation of nanoparticles on the FFL with many gradient profiles, a high-resolution, one-dimensional (1D) image can be reconstructed on the FFL. For larger magnetic nanoparticles, simulation results revealed that a pulsed excitation field with a greater flat portion generates a 1D bar pattern phantom image with a higher correlation and spatial resolution. With parallel FFL and gradient coil movements, high-resolution, two-dimensional (2D) SheppLogan phantom and brain vessel maps were reconstructed through repetition of the spatially resolvedmeasurement of magnetic nanoparticles on the FFL.
资助项目	National Key Research and Development Program of China[2017YFA0700401] ; National Natural Science Foundation of China[62027901] ; National Natural Science Foundation of China[11974267] ; 111 Project[B17035]
WOS关键词	IRON-OXIDE NANOPARTICLES ; SENSITIVITY ; RESOLUTION ; MAGNETORELAXOMETRY ; INVERSION ; FIELDS
WOS研究方向	Computer Science ; Engineering ; Imaging Science & Photographic Technology ; Radiology, Nuclear Medicine & Medical Imaging
语种	英语
出版者	IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
WOS记录号	WOS:000907324600021
资助机构	National Key Research and Development Program of China ; National Natural Science Foundation of China ; 111 Project
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/51141]
专题	自动化研究所_中国科学院分子影像重点实验室
通讯作者	Jia, Guang; Li, Tanping; Tian, Jie
作者单位	1.Jinan Univ, Zhuhai Peoples Hosp, Zhuhai Precis Med Ctr, Zhuhai 519000, Peoples R China 2.Chinese Acad Sci, Beijing Key Lab Mol Imaging, Inst Automat, Beijing 100190, Peoples R China 3.Chinese Acad Sci, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China 4.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Engn Med, Beijing 100083, Peoples R China 5.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing 100080, Peoples R China 6.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China 7.Chinese Acad Sci, CAS Key Lab Mol Imaging, Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China 8.Lanzhou Univ, Sch Phys Sci & Technol, Lanzhou 730000, Gansu, Peoples R China 9.Xidian Univ, Sch Phys, Xian 710071, Shaanxi, Peoples R China 10.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China
推荐引用方式 GB/T 7714	Jia, Guang,Huang, Liyu,Wang, Ze,et al. Gradient-Based Pulsed Excitation and Relaxation Encoding in Magnetic Particle Imaging[J]. IEEE TRANSACTIONS ON MEDICAL IMAGING,2022,41(12):3725-3733.
APA	Jia, Guang.,Huang, Liyu.,Wang, Ze.,Liang, Xiaofeng.,Zhang, Yu.,...&Tian, Jie.(2022).Gradient-Based Pulsed Excitation and Relaxation Encoding in Magnetic Particle Imaging.IEEE TRANSACTIONS ON MEDICAL IMAGING,41(12),3725-3733.
MLA	Jia, Guang,et al."Gradient-Based Pulsed Excitation and Relaxation Encoding in Magnetic Particle Imaging".IEEE TRANSACTIONS ON MEDICAL IMAGING 41.12(2022):3725-3733.