PD-L1 Aptamer-Functionalized Metal-Organic Framework Nanoparticles for Robust Photo-Immunotherapy against Cancer with Enhanced Safety

doi:10.1002/anie.202214750

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	PD-L1 Aptamer-Functionalized Metal-Organic Framework Nanoparticles for Robust Photo-Immunotherapy against Cancer with Enhanced Safety
	Zhang, Jingfang 3,4,6; Li, Wenzhe 5; Qi, Yafei 1,2,8; Wang, Guorong 1,2,8; Li, Lele 3,4; Jin, Zhengyu 1,2; Tian, Jie 7,8; Du, Yang 8
刊名	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
	2022-12-27
页码	9
关键词	DNA Nanotechnology Immunotherapy Metal-Organic Frameworks PD-L1 Aptamer Spherical Nucleic Acids (SNAs)
ISSN号	1433-7851
DOI	10.1002/anie.202214750
通讯作者	Jin, Zhengyu(jinzy@pumch.cn) ; Tian, Jie(jie.tian@ia.ac.cn) ; Du, Yang(yang.du@ia.ac.cn)
英文摘要	Immune checkpoint blockade has become a paradigm-shifting treatment modality to combat cancer, while conventional administration of immune checkpoint inhibitors, such as anti-PD-L1 antibody (alpha-PD-L1), often shows unsatisfactory immune responses and lead to severe immune-related adverse effects (irAEs). Herein, we develop a PD-L1 aptamer-based spherical nucleic acids (SNAs), which consists of oxaliplatin (OXA) encapsulated in a metal-organic framework nanoparticle core and a dense shell of aptPD-L1 (denoted as M@O-A). Upon light irradiation, this nanosystem enables concurrent photodynamic therapy (PDT), chemotherapy, and enhanced immunotherapy in one shot to inhibit both primary colorectal tumors and untreated distant tumors in mice. Notably, M@O-A shows scarcely any systemic immunotoxicity in a clinical irAEs-mimic transgenic mouse model. Collectively, this study presents a novel strategy for priming robust photo-immunotherapy against cancer with enhanced safety.
资助项目	Beijing Natural Science Foundation ; National Natural Science Foundation of China ; [7212207] ; [81871514] ; [92159303] ; [62027901] ; [82272111] ; [82003681]
WOS关键词	IN-VITRO ; DNA ; MOLECULES ; SELECTION ; TUMORS ; MICE
WOS研究方向	Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000903759600001
资助机构	Beijing Natural Science Foundation ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/51003]
专题	自动化研究所_中国科学院分子影像重点实验室
通讯作者	Jin, Zhengyu; Tian, Jie; Du, Yang
作者单位	1.Chinese Acad Med Sci, Beijing 100730, Peoples R China 2.Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Radiol, Beijing 100730, Peoples R China 3.Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China 4.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 5.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China 6.Univ Sci & Technol Beijing, Sch Chem & Biol Engn, Beijing Key Lab Bioengn & Sensing Technol, Beijing 100083, Peoples R China 7.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Beijing 100191, Peoples R China 8.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing Key Lab Mol Imaging,State Key Lab Manageme, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Jingfang,Li, Wenzhe,Qi, Yafei,et al. PD-L1 Aptamer-Functionalized Metal-Organic Framework Nanoparticles for Robust Photo-Immunotherapy against Cancer with Enhanced Safety[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2022:9.
APA	Zhang, Jingfang.,Li, Wenzhe.,Qi, Yafei.,Wang, Guorong.,Li, Lele.,...&Du, Yang.(2022).PD-L1 Aptamer-Functionalized Metal-Organic Framework Nanoparticles for Robust Photo-Immunotherapy against Cancer with Enhanced Safety.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,9.
MLA	Zhang, Jingfang,et al."PD-L1 Aptamer-Functionalized Metal-Organic Framework Nanoparticles for Robust Photo-Immunotherapy against Cancer with Enhanced Safety".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022):9.