Numerical simulation of flow characteristics in a permeable liver sinusoid with leukocytes

doi:10.1016/j.bpj.2022.10.022

CORC > 力学研究所 > 中国科学院力学研究所 > 非线性力学国家重点实验室

	Numerical simulation of flow characteristics in a permeable liver sinusoid with leukocytes
	Chen, Shenbao 4,5; Zhu, Jingchen 4,5; Xue, Jian 3,4; Wang, Xiaolong 2; Jing, Peng 2; Zhou, Luwen 4,5; Cui, Yuhong 1; Wang, Tianhao 1; Gong, Xiaobo 2; Lu, Shouqin 4,5
刊名	BIOPHYSICAL JOURNAL
	2022-12-06
卷号	121 期号:23 页码:4666-4678
ISSN号	0006-3495
DOI	10.1016/j.bpj.2022.10.022
通讯作者	Gong, Xiaobo(x.gong@sjtu.edu.cn) ; Lu, Shouqin(lsq@imech.ac.cn) ; Long, Mian(mlong@imech.ac.cn)
英文摘要	Double-layered channels of sinusoid lumen and Disse space separated by fenestrated liver sinusoidal endothelial cells (LSECs) endow the unique mechanical environment of the liver sinusoid network, which further guarantees its biological function. It is also known that this mechanical environment changes dramatically under liver fibrosis and cirrhosis, including the reduced plasma penetration and metabolite exchange between the two flow channels and the reduced Disse space deformabil-ity. The squeezing of leukocytes through narrow sinusoid lumen also affects the mechanical environment of liver sinusoid. To date, the detailed flow-field profile of liver sinusoid is still far from clear due to experimental limitations. It also remains elusive whether and how the varied physical properties of the pathological liver sinusoid regulate the fluid flow characteristics. Here a numerical model based on the immersed boundary method was established, and the effects of Disse space and leukocyte elas-ticities, endothelium permeability, and sinusoidal stenosis degree on fluid flow as well as leukocyte trafficking were specified upon a mimic liver sinusoid structure. Results showed that endothelium permeability dominantly controlled the plasma penetra-tion velocity across the endothelium, whereas leukocyte squeezing promoted local penetration and significantly regulated wall shear stress on hepatocytes, which was strongly related to the Disse space and leukocyte deformability. Permeability and elas-ticity cooperatively regulated the process of leukocytes trafficking through the liver sinusoid, especially for stiffer leukocytes. This study will offer new insights into deeper understanding of the elaborate mechanical features of liver sinusoid and corresponding biological function.
资助项目	National Natural Science Foundation of China ; Scientific Instrument Developing Project of Chinese Academy of Sciences ; [32130061] ; [11972042] ; [12072198] ; [GJJSTU20190005]
WOS关键词	BLOOD-FLOW ; HEPATOCYTE FUNCTION ; CELLS ; NEUTROPHILS ; MODEL
WOS研究方向	Biophysics
语种	英语
WOS记录号	WOS:000901491100002
资助机构	National Natural Science Foundation of China ; Scientific Instrument Developing Project of Chinese Academy of Sciences
内容类型	期刊论文
源URL	[http://dspace.imech.ac.cn/handle/311007/91386]
专题	力学研究所_非线性力学国家重点实验室
通讯作者	Gong, Xiaobo; Lu, Shouqin; Long, Mian
作者单位	1.Tianjin Univ, Dept Mech, Tianjin, Peoples R China 2.Shanghai Jiao Tong Univ, Shanghai, Peoples R China 3.Inst Mech, Chinese Acad Sci, State Key Lab Nonlinear Mech LNM, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Sch Engn Sci, Beijing, Peoples R China 5.Chinese Acad Sci, Inst Mech, Ctr Biomech & Bioengn, CAS Ctr Excellence Complex Syst Mech, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Chen, Shenbao,Zhu, Jingchen,Xue, Jian,et al. Numerical simulation of flow characteristics in a permeable liver sinusoid with leukocytes[J]. BIOPHYSICAL JOURNAL,2022,121(23):4666-4678.
APA	Chen, Shenbao.,Zhu, Jingchen.,Xue, Jian.,Wang, Xiaolong.,Jing, Peng.,...&Long, Mian.(2022).Numerical simulation of flow characteristics in a permeable liver sinusoid with leukocytes.BIOPHYSICAL JOURNAL,121(23),4666-4678.
MLA	Chen, Shenbao,et al."Numerical simulation of flow characteristics in a permeable liver sinusoid with leukocytes".BIOPHYSICAL JOURNAL 121.23(2022):4666-4678.