Non-invasive molecular imaging for precision diagnosis of metastatic lymph nodes: opportunities from preclinical to clinical applications

doi:10.1007/s00259-022-06056-5

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	Non-invasive molecular imaging for precision diagnosis of metastatic lymph nodes: opportunities from preclinical to clinical applications
	Cheng, Zhongquan 4,5; Ma, Jiaojiao 3; Yin, Lin 2,4; Yu, Leyi 5; Yuan, Zhu 5; Zhang, Bo 3; Tian, Jie 1,4; Du, Yang 2,4
刊名	EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
	2022-11-29
页码	23
关键词	Molecular imaging Lymph node metastasis Cancer Imaging probes Imaging biomarkers
ISSN号	1619-7070
DOI	10.1007/s00259-022-06056-5
通讯作者	Yuan, Zhu(BJFH_yz_paper@163.com) ; Zhang, Bo(thyroidus@163.com) ; Tian, Jie(tian@ieee.org) ; Du, Yang(yang.du@ia.ac.cn)
英文摘要	Lymph node metastasis is an indicator of the invasiveness and aggressiveness of cancer. It is a vital prognostic factor in clinical staging of the disease and therapeutic decision-making. Patients with positive metastatic lymph nodes are likely to develop recurrent disease, distant metastasis, and succumb to death in the coming few years. Lymph node dissection and histological analysis are needed to detect whether regional lymph nodes have been infiltrated by cancer cells and determine the likely outcome of treatment and the patient's chances of survival. However, these procedures are invasive, and tissue biopsies are prone to sampling error. In recent years, advanced molecular imaging with novel imaging probes has provided new technologies that are contributing to comprehensive management of cancer, including non-invasive investigation of lymphatic drainage from tumors, identifying metastatic lymph nodes, and guiding surgeons to operate efficiently in patients with complex lesions. In this review, first, we outline the current status of different molecular imaging modalities applied for lymph node metastasis management. Second, we summarize the multi-functional imaging probes applied with the different imaging modalities as well as applications of cancer lymph node metastasis from preclinical studies to clinical translations. Third, we describe the limitations that must be considered in the field of molecular imaging for improved detection of lymph node metastasis. Finally, we propose future directions for molecular imaging technology that will allow more personalized treatment plans for patients with lymph node metastasis.
资助项目	Beijing Natural Science Foundation[7212207] ; National Natural Science Foundation of China[62027901] ; National Natural Science Foundation of China[81871514] ; National Natural Science Foundation of China[81227901]
WOS关键词	EPITHELIAL-MESENCHYMAL TRANSITION ; SQUAMOUS-CELL CARCINOMA ; BREAST-CANCER ; INDOCYANINE GREEN ; EXTRACELLULAR VESICLES ; ADVERSE-REACTIONS ; TIM-3 EXPRESSION ; GUIDED SURGERY ; OVARIAN-CANCER ; FLUORESCENCE
WOS研究方向	Radiology, Nuclear Medicine & Medical Imaging
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000889438400001
资助机构	Beijing Natural Science Foundation ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/50833]
专题	自动化研究所_中国科学院分子影像重点实验室
通讯作者	Yuan, Zhu; Zhang, Bo; Tian, Jie; Du, Yang
作者单位	1.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med Sci & Engn, Beijing 100191, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100080, Peoples R China 3.China Japan Friendship Hosp, Dept Med Ultrason, Yinghua East Rd 2, Beijing 100029, Peoples R China 4.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China 5.Capital Med Univ, Beijing Friendship Hosp, Dept Gen Surg, Beijing 100050, Peoples R China
推荐引用方式 GB/T 7714	Cheng, Zhongquan,Ma, Jiaojiao,Yin, Lin,et al. Non-invasive molecular imaging for precision diagnosis of metastatic lymph nodes: opportunities from preclinical to clinical applications[J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING,2022:23.
APA	Cheng, Zhongquan.,Ma, Jiaojiao.,Yin, Lin.,Yu, Leyi.,Yuan, Zhu.,...&Du, Yang.(2022).Non-invasive molecular imaging for precision diagnosis of metastatic lymph nodes: opportunities from preclinical to clinical applications.EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING,23.
MLA	Cheng, Zhongquan,et al."Non-invasive molecular imaging for precision diagnosis of metastatic lymph nodes: opportunities from preclinical to clinical applications".EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2022):23.