C-phycocyanin alleviated cisplatin-induced oxidative stress and inflammation via gut microbiota-metabolites axis in mice

doi:10.3389/fnut.2022.996614

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 海岸带生物学与生物资源利用重点实验室

	C-phycocyanin alleviated cisplatin-induced oxidative stress and inflammation via gut microbiota-metabolites axis in mice
	Zhang, Yubing 4,5; Li, Lili 3,4; Qin, Song 3,4; Yuan, Jingyi 4; Xie, Xiaonan 2,5; Wang, Fan 2,5; Hu, Shanliang 1; Yi, Yuetao 3,4; Chen, Min 5
刊名	FRONTIERS IN NUTRITION
	2022-09-20
卷号	9 页码:17
关键词	C-phycocyanin cisplatin gut microbiota metabolomics inflammation oxidative stress FAHFAs chemotherapy
ISSN号	2296-861X
DOI	10.3389/fnut.2022.996614
英文摘要	C-phycocyanin is a natural protein extracted from Spirulina platensis. We aim to investigate the preventive effect of C-phycocyanin on cisplatin chemotherapy-induced oxidative damage and inflammation. The result showed that C-phycocyanin treatment reduced cisplatin-induced mortality and inflammation including decreased levels of serum IL6, kidney MCP1, and liver IL1 beta. Furthermore, C-phycocyanin also exerted antioxidant effects on mice, including increased GSH-Px, GGT, and GSH levels in the liver and increased CAT and SOD levels in the kidney. HepG2 cells experiments showed that C-phycocyanin exhibited none of the prevention effects on cisplatin injury. Faecalibaculum showed the greatest reduction among genera after cisplatin treatment, which was related to the enrichment of Romboutsia and Lactobacillus genera. C-phycocyanin treatment reduced the populations of harmful bacteria of Enterococcus faecalis, which was positively correlated with inflammation induced by cisplatin. C-phycocyanin increased the contents of 23-nordeoxycholic acid and beta-muricholic acid. Moreover, C-phycocyanin increased amino acid-related metabolites, N-alpha-acetyl-arginine and trimethyl-lysine contents, and decreased fatty acid esters of hydroxy fatty acids (FAHFAs) contents. In conclusion, C-phycocyanin inhibited inflammation via the 23-nordeoxycholic acid-Enterococcus faecalis-inflammation axis, and enhanced the antioxidant capacity of kidney via Lactobacillus-NRF2 pathway. C-phycocyanin alleviated cisplatin injury via the modulation of gut microbiota, especially Lactobacillus and Enterococcus, as well as regulation of metabolites, especially bile acid and FAHFAs, which highlight the effect of C-phycocyanin and provide a new strategy to prevent cisplatin injury.
资助项目	Science and Technology Program of Yantai ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; [2020MSGY076] ; [2018246]
WOS研究方向	Nutrition & Dietetics
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000872943200001
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/31800]
专题	海岸带生物学与生物资源利用重点实验室
通讯作者	Li, Lili
作者单位	1.Yantai Yuhuangding Hosp, Dept Radiotherapy, Yantai, Peoples R China 2.Yantai Univ, Coll Life Sci, Ctr Mitochondria & Hlth Aging, Yantai, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao, Peoples R China 4.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai, Peoples R China 5.Yantai Univ, Coll Life Sci, Yantai, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Yubing,Li, Lili,Qin, Song,et al. C-phycocyanin alleviated cisplatin-induced oxidative stress and inflammation via gut microbiota-metabolites axis in mice[J]. FRONTIERS IN NUTRITION,2022,9:17.
APA	Zhang, Yubing.,Li, Lili.,Qin, Song.,Yuan, Jingyi.,Xie, Xiaonan.,...&Chen, Min.(2022).C-phycocyanin alleviated cisplatin-induced oxidative stress and inflammation via gut microbiota-metabolites axis in mice.FRONTIERS IN NUTRITION,9,17.
MLA	Zhang, Yubing,et al."C-phycocyanin alleviated cisplatin-induced oxidative stress and inflammation via gut microbiota-metabolites axis in mice".FRONTIERS IN NUTRITION 9(2022):17.