Toxicokinetics and toxicodynamics of plastic and metallic nanoparticles: A comparative study in shrimp

doi:10.1016/j.envpol.2022.120069

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 中国科学院牟平海岸带环境综合试验站

	Toxicokinetics and toxicodynamics of plastic and metallic nanoparticles: A comparative study in shrimp
	Zhu, Xiaopeng 2,3,4; Teng, Jia 2,3,4; Xu, Elvis Genbo 1; Zhao, Jianmin 3,4; Shan, Encui 2,3,4; Sun, Chaofan 2,3,4; Wang, Qing 3,4
刊名	ENVIRONMENTAL POLLUTION
	2022-11-01
卷号	312 页码:12
关键词	Nanoplastics Titanium dioxide nanoparticle Litopenaeus vannamei Bioaccumulation Toxic effect Intestinal microbiota
ISSN号	0269-7491
DOI	10.1016/j.envpol.2022.120069
英文摘要	Nanoplastic is recognized as an emerging environmental pollutant due to the anticipated ubiquitous distribution, increasing concentration in the ocean, and potential adverse health effects. While our understanding of the ecological impacts of nanoplastics is still limited, we benefit from relatively rich toxicological studies on other nanoparticles such as nano metal oxides. However, the similarity and difference in the toxicokinetic and tox-icodynamic aspects of plastic and metallic nanoparticles remain largely unknown. In this study, juvenile Pacific white shrimp Litopenaeus vannamei was exposed to two types of nanoparticles at environmentally relative low and high concentrations, i.e., 100 nm polystyrene nanoplastics (nano-PS) and titanium dioxide nanoparticles (nano-TiO2) via dietary exposure for 28 days. The systematic toxicological evaluation aimed to quantitatively compare the accumulation, excretion, and toxic effects of nano-PS and nano-TiO2. Our results demonstrated that both nanoparticles were ingested by L. vannamei with lower egestion of nano-TiO2 than nano-PS. Both nano -particles inhibited the growth of shrimps, damaged tissue structures of the intestine and hepatopancreas, dis-rupted expression of immune-related genes, and induced intestinal microbiota dysbiosis. Nano-PS exposure caused proliferative cells in the intestinal tissue, and the disturbance to the intestinal microbes was also more serious than that of nano-TiO2. The results indicated that the effect of nano-PS on the intestinal tissue of L. vannamei was more severe than that of nano-TiO2 with the same particle size. The study provides new theoretical basis of the similarity and differences of their toxicity, and highlights the current lack of knowledge on various aspects of absorption, distribution, metabolism, and excretion (ADME) pathways of nanoplastics.
资助项目	Strategic Priority Research Program of the Chinese Academy of Sciences[XDA23050303] ; National Key Research and Development Project[2019YFD0901101] ; National Natural Science Fund of China[42176161] ; Two-Hundred Talents Plan of Yantai[Y839081021]
WOS关键词	GLUCAN BINDING-PROTEIN ; NANO-TITANIUM-DIOXIDE ; POLYSTYRENE MICROPLASTICS ; OXIDATIVE STRESS ; TIO2 NANOPARTICLES ; DAPHNIA-MAGNA ; TOXICITY ; MICROBIOTA ; ACCUMULATION ; NANOPLASTICS
WOS研究方向	Environmental Sciences & Ecology
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000860790500001
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/31741]
专题	中国科学院牟平海岸带环境综合试验站
通讯作者	Wang, Qing
作者单位	1.Univ Southern Denmark, Dept Biol, DK-5230 Odense, Denmark 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Muping Coastal Environm Res Stn, Yantai 264003, Peoples R China 4.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res & Dev Ctr Efficient Utilizat Coastal Bioresour, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Xiaopeng,Teng, Jia,Xu, Elvis Genbo,et al. Toxicokinetics and toxicodynamics of plastic and metallic nanoparticles: A comparative study in shrimp[J]. ENVIRONMENTAL POLLUTION,2022,312:12.
APA	Zhu, Xiaopeng.,Teng, Jia.,Xu, Elvis Genbo.,Zhao, Jianmin.,Shan, Encui.,...&Wang, Qing.(2022).Toxicokinetics and toxicodynamics of plastic and metallic nanoparticles: A comparative study in shrimp.ENVIRONMENTAL POLLUTION,312,12.
MLA	Zhu, Xiaopeng,et al."Toxicokinetics and toxicodynamics of plastic and metallic nanoparticles: A comparative study in shrimp".ENVIRONMENTAL POLLUTION 312(2022):12.