Fucoidan, as an immunostimulator promotes M1 macrophage differentiation and enhances the chemotherapeutic sensitivity of capecitabine in colon cancer

doi:10.1016/j.ijbiomac.2022.09.201

CORC > 海洋研究所 > 中国科学院海洋研究所 > 实验海洋生物学重点实验室

	Fucoidan, as an immunostimulator promotes M1 macrophage differentiation and enhances the chemotherapeutic sensitivity of capecitabine in colon cancer
	Deng, Zhenzhen 1,2,3,4; Wu, Ning 1,2,5; Suo, Qishan 2,4; Wang, Jing 1,2,3; Yue, Yang 1,2,3; Geng, Lihua 1,2,3; Zhang, Quanbin 1,2,3
刊名	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
	2022-12-01
卷号	222 页码:562-572
关键词	Capecitabine Tumor microenvironment Macrophages TLR4 Fucoidan
ISSN号	0141-8130
DOI	10.1016/j.ijbiomac.2022.09.201
通讯作者	Wu, Ning(wuning@qdio.ac.cn) ; Zhang, Quanbin(qbzhang@qdio.ac.cn)
英文摘要	Chemotherapy resistance is one of the most critical challenges in colorectal cancer (CRC) treatment. The occurrence and development of chemotherapy resistance closely related to the tumor immune microenvironment (TIME). As the most important immunosuppressive immune cells infiltrating into the TIME, macrophages are essential for chemotherapy resistance in CRC treatment. In this study, we found that a kind of fucoidan (FPS1M) induced macrophages differentiation to the M1 phenotype, and this transformation promoted cancer cells apoptosis both in vitro and in vivo. TNF alpha is a key mediator of FPS1M-induced tumorcidal activity of macrophages. Mechanistically, as a stimulator of TLR4, FPS1M enhanced macrophages glycolysis and regulated macrophages differentiation to the M1 phenotype by the activation of TLR4 mediated PI3K/AKT/mTOR signaling axis. In addition, FPS1M improved the immunosuppressed tumor microenvironment by increasing the infiltration of M1 macrophages in tumor tissue, which was conducive to improving the sensitivity of tumor to chemotherapy. Collectively, our findings demonstrated that FPS1M has the great potential to be used in tumor immunotherapy. The results also suggested that the combination of FPS1M with capecitabine is an alternative therapy method for colon cancer.
资助项目	National Natural Science Foundation of China ; Major Scientific & Engineering Projects of Innovation in Shandong Province ; [81872906] ; [42176137] ; [2019JZZY010818]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000876352600006
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/180539]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Wu, Ning; Zhang, Quanbin
作者单位	1.Chinese Acad Sci, CAS, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 3.Qingdao Natl Lab Marine Sci & Tech, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Pilot Natl Lab Marine Sci & Technol, Lab Marine drugs & Biol Prod, Qingdao, Peoples R China
推荐引用方式 GB/T 7714	Deng, Zhenzhen,Wu, Ning,Suo, Qishan,et al. Fucoidan, as an immunostimulator promotes M1 macrophage differentiation and enhances the chemotherapeutic sensitivity of capecitabine in colon cancer[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2022,222:562-572.
APA	Deng, Zhenzhen.,Wu, Ning.,Suo, Qishan.,Wang, Jing.,Yue, Yang.,...&Zhang, Quanbin.(2022).Fucoidan, as an immunostimulator promotes M1 macrophage differentiation and enhances the chemotherapeutic sensitivity of capecitabine in colon cancer.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,222,562-572.
MLA	Deng, Zhenzhen,et al."Fucoidan, as an immunostimulator promotes M1 macrophage differentiation and enhances the chemotherapeutic sensitivity of capecitabine in colon cancer".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 222(2022):562-572.