Injectable magnetic montmorillonite colloidal gel for the postoperative treatment of hepatocellular carcinoma

doi:10.1186/s12951-022-01559-7

	Injectable magnetic montmorillonite colloidal gel for the postoperative treatment of hepatocellular carcinoma
	Chen, Sheng 4; Song, Yonghong 4; Yan, Xu 4; Dong, Liang 1,3; Xu, Yunjun 3; Xuan, Shouhu 3; Shu, Quan 3; Cao, Baoqiang 2; Hu, Jinlong 2; Xing, Hanye 4
刊名	JOURNAL OF NANOBIOTECHNOLOGY
	2022-08-19
卷号	20
关键词	Colloidal gel Magnetic hyperthermia Hepatocellular carcinoma Postoperative therapy Hemostasis
DOI	10.1186/s12951-022-01559-7
通讯作者	Dong, Liang(dldisc@ustc.edu.cn) ; Zha, Zhengbao(zbzha@hfut.edu.cn) ; Lu, Yang(yanglu@hfut.edu.cn)
英文摘要	Bioactive materials have been extensively developed for the adjuvant therapy of cancer. However, few materials can meet the requirements for the postoperative resection of hepatocellular carcinoma (HCC) due to massive bleeding and high recurrence. In particular, combination therapy for HCC has been highly recommended in clinical practice, including surgical resection, interventional therapy, ablation therapy and chemotherapy. Herein, an injectable magnetic colloidal gel (MCG) was developed by controllable electrostatic attraction between clinically available magnetic montmorillonites and amphoteric gelatin nanoparticles. The optimized MCG exhibited an effective magnetic heating effect, remarkable rheological properties, and high gel network stability, realizing the synergistic treatment of postoperative HCC by stimuli-responsive drug delivery, hemostasis and magnetic hyperthermia. Furthermore, a minimal invasive MCG-induced interventional magnetic hyperthermia therapy (MHT) under ultrasound guidance was realized on hepatic tumor rabbits, providing an alternative therapeutics to treat the postoperative recurrence. Overall, MCG is a clinically available injectable formulation for adjuvant therapy after HCC surgical resection.
资助项目	National Natural Science Foundation of China[51972090] ; National Natural Science Foundation of China[22122502] ; National Natural Science Foundation of China[22105195] ; National Natural Science Foundation of China[51702309] ; National Natural Science Foundation of China[51572067] ; National Natural Science Foundation of China[21501039] ; Fundamental Research Funds for the Central Universities[JZ2021HGPB0059] ; Fundamental Research Funds for the Central Universities[JZ2021HGQB0279] ; Fundamental Research Funds for the Central Universities[WK2060000033] ; Fundamental Research Funds for the Central Universities[WK9110000062] ; Anhui Provincial Natural Science Foundation[2008085J06] ; University Synergy Innovation Program of Anhui Province[GXXT-2020-063] ; University Synergy Innovation Program of Anhui Province[GXXT-2021066] ; China Postdoctoral Science Foundation[BH2060000173] ; National Key Research and Development Program of China[2018YFE0202201]
WOS关键词	GELATIN NANOSPHERES ; CANCER ; THERMOTHERAPY ; RECURRENCE ; SURGERY
WOS研究方向	Biotechnology & Applied Microbiology ; Science & Technology - Other Topics
语种	英语
出版者	BMC
WOS记录号	WOS:000843254600002
资助机构	National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; Anhui Provincial Natural Science Foundation ; University Synergy Innovation Program of Anhui Province ; China Postdoctoral Science Foundation ; National Key Research and Development Program of China
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/132053]
专题	中国科学院合肥物质科学研究院
通讯作者	Dong, Liang; Zha, Zhengbao; Lu, Yang
作者单位	1.Chinese Acad Sci, Univ Chinese Acad Sci, Zhejiang Canc Hosp, Inst Basic Med & Canc IBMC,Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China 2.Anhui 2 Prov Peoples Hosp, Dept Gen Surg, Dept Ultrason, Dept Intervent Radiol, Hefei 230041, Anhui, Peoples R China 3.Univ Sci & Technol China, Affiliated Hosp 1, Dept Modern Mech, Div Nanomat & Chem,Dept Radiol,Hefei Natl Lab Phy, Hefei 230026, Peoples R China 4.Hefei Univ Technol, Sch Chem & Chem Engn, Sch Food & Biol Engn, Anhui Key Lab Adv Catalyt Mat & React Engn, Hefei 230009, Peoples R China
推荐引用方式 GB/T 7714	Chen, Sheng,Song, Yonghong,Yan, Xu,et al. Injectable magnetic montmorillonite colloidal gel for the postoperative treatment of hepatocellular carcinoma[J]. JOURNAL OF NANOBIOTECHNOLOGY,2022,20.
APA	Chen, Sheng.,Song, Yonghong.,Yan, Xu.,Dong, Liang.,Xu, Yunjun.,...&Lu, Yang.(2022).Injectable magnetic montmorillonite colloidal gel for the postoperative treatment of hepatocellular carcinoma.JOURNAL OF NANOBIOTECHNOLOGY,20.
MLA	Chen, Sheng,et al."Injectable magnetic montmorillonite colloidal gel for the postoperative treatment of hepatocellular carcinoma".JOURNAL OF NANOBIOTECHNOLOGY 20(2022).