Vanguard is a Glucose Deprivation-Responsive Long Non-Coding RNA Essential for Chromatin Remodeling-Reliant DNA Repair

doi:10.1002/advs.202201210

	Vanguard is a Glucose Deprivation-Responsive Long Non-Coding RNA Essential for Chromatin Remodeling-Reliant DNA Repair
	Zhang, Ben 2; Thorne, Rick Francis 3; Zhang, Pengfei 2,4; Wu, Mian 2,3; Liu, Lianxin 1,2,5
刊名	ADVANCED SCIENCE
	2022-09-01
关键词	genomic stability HMGB1 long non-coding RNAs PARP inhibitors Vanguard
DOI	10.1002/advs.202201210
通讯作者	Zhang, Pengfei(zpf1990@ustc.edu.cn) ; Wu, Mian(wumian@ustc.edu.cn) ; Liu, Lianxin(liulx@ustc.edu.cn)
英文摘要	Glucose metabolism contributes to DNA damage response pathways by regulating chromatin remodeling, double-strand break (DSB) repair, and redox homeostasis, although the underlying mechanisms are not fully established. Here, a previously uncharacterized long non-coding RNA is revealed that is call Vanguard which acts to promote HMGB1-dependent DNA repair in association with changes in global chromatin accessibility. Vanguard expression is maintained in cancer cells by SP1-dependent transcription according to glucose availability and cellular adenosine triphosphate (ATP) levels. Vanguard promotes complex formation between HMGB1 and HDAC1, with the resulting deacetylation of HMGB1 serving to maintain its nuclear localization and DSB repair function. However, Vanguard downregulation under glucose limiting conditions promotes HMGB1 translocation from the nucleus, increasing DNA damage, and compromising cancer cell growth and viability. Moreover, Vanguard silencing increases the effectiveness of poly (ADP-ribose) polymerase inhibitors against breast cancer cells with wild-type breast cancer gene-1 status, suggesting Vanguard as a potential therapeutic target.
资助项目	National Natural Science Foundation of China[81820108021] ; National Natural Science Foundation of China[U19A2008] ; National Natural Science Foundation of China[81972307] ; National Natural Science Foundation of China[31871437] ; National Natural Science Foundation of China[32000526] ; National Key R&D Program of China[2019YFA0709300] ; China Postdoctoral Science Foundation[2021T140646]
WOS关键词	STRAND BREAK REPAIR ; UP-REGULATION ; CANCER ; HISTONE ; HMGB1 ; EXPRESSION ; METABOLISM ; DYNAMICS ; PROTEIN ; DAMAGE
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	WILEY
WOS记录号	WOS:000848253500001
资助机构	National Natural Science Foundation of China ; National Key R&D Program of China ; China Postdoctoral Science Foundation
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/131824]
专题	中国科学院合肥物质科学研究院
通讯作者	Zhang, Pengfei; Wu, Mian; Liu, Lianxin
作者单位	1.First Affiliated Hosp USTC, Anhui Prov Clin Res Ctr Hepatobiliary Dis, Hefei 230001, Anhui, Peoples R China 2.Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Hepatobiliary Surg, Div Life Sci & Med, Hefei 230001, Anhui, Peoples R China 3.Zhengzhou Univ, Henan Int Join Lab Noncoding RNA & Metab Canc, Henan Prov & Zhengzhou City Key Lab Noncoding RNA, Acad Med Sci,Peoples Hosp, Zhengzhou 450053, Henan, Peoples R China 4.Chinese Acad Sci, Canc Hosp, Univ Chinese Acad Sci, Inst Basic Med & Canc IBMC, Hangzhou 310022, Zhejiang, Peoples R China 5.First Affiliated Hosp USTC, Anhui Prov Key Lab Hepatopancreatobiliary Surg, Hefei 230001, Anhui, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Ben,Thorne, Rick Francis,Zhang, Pengfei,et al. Vanguard is a Glucose Deprivation-Responsive Long Non-Coding RNA Essential for Chromatin Remodeling-Reliant DNA Repair[J]. ADVANCED SCIENCE,2022.
APA	Zhang, Ben,Thorne, Rick Francis,Zhang, Pengfei,Wu, Mian,&Liu, Lianxin.(2022).Vanguard is a Glucose Deprivation-Responsive Long Non-Coding RNA Essential for Chromatin Remodeling-Reliant DNA Repair.ADVANCED SCIENCE.
MLA	Zhang, Ben,et al."Vanguard is a Glucose Deprivation-Responsive Long Non-Coding RNA Essential for Chromatin Remodeling-Reliant DNA Repair".ADVANCED SCIENCE (2022).