Preoperative chemotherapy combined with para-aortic lymph node dissection has clinical value in the treatment of gastric cancer with para-aortic lymph node metastases | |
Yu, Pengcheng1; Hu, Can2; Wang, Yi1; Bao, Zhehan1; Zhang, Ruolan2; Cao, Mengxuan3; Zhang, Yanqiang4; Cheng, Xiangdong4; Xu, Zhiyuan4 | |
刊名 | BMC SURGERY |
2022-11-20 | |
卷号 | 22 |
关键词 | Gastric cancer Para-aortic lymph node dissection Para-aortic lymph node metastasis Chemotherapy |
DOI | 10.1186/s12893-022-01844-0 |
通讯作者 | Zhang, Yanqiang(zyq201003@163.com) ; Cheng, Xiangdong(chengxd@zjcc.org.cn) ; Xu, Zhiyuan(xuzy@zjcc.org.cn) |
英文摘要 | Background Lymph node metastases often occur in advanced gastric cancer, with some patients presenting with metastases in the para-aortic lymph nodes. There are persistent Controversies about the benefit of para-aortic lymph node dissection (PAND). Our purpose is to probe whether PAND following preoperative chemotherapy had any clinical significance in individuals with PALNs in gastric cancer. Material and methods To retrospectively analyze the clinical data of 86 gastric cancer patients (40 in the D2 + PAND group and 46 in the D2 group) who attended the abdominal surgery department of Zhejiang Cancer Hospital between September 1, 2008, and July 30, 2018. Results In the D2 + PAND group (40 cases), the average number of lymph nodes cleared per case was 4.3 in group 16 (16a2, 16b1), and the postoperative pathology confirmed lymph node positivity in 16 cases, with a metastasis rate of 40%. The median overall survival times were 63 and 34 months for the patients in the D2 + PAND group and D2 group, respectively. The 3-year overall survival (OS) compared to the D2 group (D2 + PAND 69.1% vs. D2 50%, P = 0.012) and a statistically significant difference in 3-year disease-free survival (DFS) (D2 + PAND 69.6% vs. D2 38.3%, P = 0.007). Lymph node dissection extent and recurrence of para-aortic lymph nodes were independent prognostic variables for the patients. The recurrence rate was reduced in the D2 + PAND group compared to the D2 group (D2 + PAND 7.5% vs. D2 26.1%, p = 0.023). Conclusions For patients with gastric cancer whose imaging suggests metastasis in the para-aortic lymph nodes, preoperative chemotherapy combined with PAND is an effective and safe treatment that may benefit patient survival. |
资助项目 | National Natural Science Foundation of China[81973634] ; Program of Zhejiang Provincial TCM Sci-tech Plan[2019ZZ010] ; Zhejiang Provincial Research Center for Upper Gastrointestinal Tract Cancer[JBZX-202006] |
WOS关键词 | NEOADJUVANT CHEMOTHERAPY ; PHASE-II ; D2 GASTRECTOMY ; LYMPHADENECTOMY ; CISPLATIN ; SURGERY ; S-1 |
WOS研究方向 | Surgery |
语种 | 英语 |
出版者 | BMC |
WOS记录号 | WOS:000885837300001 |
资助机构 | National Natural Science Foundation of China ; Program of Zhejiang Provincial TCM Sci-tech Plan ; Zhejiang Provincial Research Center for Upper Gastrointestinal Tract Cancer |
内容类型 | 期刊论文 |
源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/131652] |
专题 | 中国科学院合肥物质科学研究院 |
通讯作者 | Zhang, Yanqiang; Cheng, Xiangdong; Xu, Zhiyuan |
作者单位 | 1.Chinese Med Univ, Clin Med Coll Zhejiang 1, Hangzhou 310053, Peoples R China 2.Chinese Med Univ, Clin Med Coll Zhejiang 2, Hangzhou 310053, Peoples R China 3.Wenzhou Med Univ, Wenzhou 325035, Peoples R China 4.Chinese Acad Sci, Univ Chinese Acad Sci, Canc Hosp, Zhejiang Canc Hosp,Inst Basic Med & Canc IBMC, Banshan Rd 1, Hangzhou 310022, Zhejiang, Peoples R China |
推荐引用方式 GB/T 7714 | Yu, Pengcheng,Hu, Can,Wang, Yi,et al. Preoperative chemotherapy combined with para-aortic lymph node dissection has clinical value in the treatment of gastric cancer with para-aortic lymph node metastases[J]. BMC SURGERY,2022,22. |
APA | Yu, Pengcheng.,Hu, Can.,Wang, Yi.,Bao, Zhehan.,Zhang, Ruolan.,...&Xu, Zhiyuan.(2022).Preoperative chemotherapy combined with para-aortic lymph node dissection has clinical value in the treatment of gastric cancer with para-aortic lymph node metastases.BMC SURGERY,22. |
MLA | Yu, Pengcheng,et al."Preoperative chemotherapy combined with para-aortic lymph node dissection has clinical value in the treatment of gastric cancer with para-aortic lymph node metastases".BMC SURGERY 22(2022). |
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