Zinc oxide/graphene oxide nanocomposites efficiently inhibited cadmium-induced hepatotoxicity via releasing Zn ions and up-regulating MRP1 expression

doi:10.1016/j.envint.2022.107327

	Zinc oxide/graphene oxide nanocomposites efficiently inhibited cadmium-induced hepatotoxicity via releasing Zn ions and up-regulating MRP1 expression
	Liu, Yun 2,5,6; Wang, Xue 3,5,7; Si, Bo 2,5,6; Wang, Tong 2,5,6; Wu, Yun 1,4,5; Liu, Ying 2,5,6; Zhou, Yemian 2,5,6; Tong, Haiyang 1,4,5; Zheng, Xinwei 1,4,5; Xu, An 2,5,6
刊名	ENVIRONMENT INTERNATIONAL
	2022-07-01
卷号	165
关键词	Cadmium Zinc oxide Graphene oxide Detoxification Bioaccumulation Magnetic resonance imaging
ISSN号	0160-4120
DOI	10.1016/j.envint.2022.107327
通讯作者	Zheng, Xinwei(xwzheng@hmfl.ac.cn) ; Xu, An(anxu@ipp.ac.cn)
英文摘要	Environmental cadmium (Cd) pollution has been verified to associated with various hepatic diseases, as Cd has been classified as one of the TOP 20 Hazardous Substances and liver is the main target of Cd poisoning. However, to design efficient hepatic antidotes with excellent detoxification capacity and reveal their underlying mechanism(s) are still challenges in Cd detoxification. Herein, ZnO/GO nanocomposites with favorable biocompatibility was uncovered their advanced function against Cd-elicited liver damage at the in situ level in vivo by 9.4 T magnetic resonance imaging (MRI). To explore the cellular detoxification mechanism, ZnO/GO nanocomposites was found to effectively inhibit the cyto- and geno-toxicity of Cd with the maximum antagonistic efficiency to be approximately 90%. Mechanistically, ZnO/GO nanocomposites competitively inhibited the cellular Cd uptake through releasing Zn ions, and significantly promoted Cd excretion via targeting the efflux pump of multidrug resistance associated protein1 (MRP1), which was confirmed by mass spectra and immunohistochemical analysis in kidney, a main excretion organ of Cd. Our data provided a novel approach against Cd-elicited hepatotoxic responses by constructed ZnO/GO nanocomposites both in vitro and in vivo, which may have promising application in prevention and detoxification for Cd poisoning.
资助项目	National Natural Science Foundation of China[22076191] ; Youth Innovation Promotion Association of CAS[2020444] ; Anhui Provincial Key RD Programs[202004i07020015] ; Anhui Provincial Key RD Programs[201904a07020098] ; Collaborative Innovation Program of Hefei Science Center, CAS[2021HSC-CIP003] ; Dean's Fund of Hefei Institute of Physical Science[YZJJZX202014] ; National Key R&D Program of China[2018YFE0205700] ; High Magnetic Field Laboratory of Anhui Province
WOS关键词	GRAPHENE OXIDE ; TOXICITY ; ACTIVATION
WOS研究方向	Environmental Sciences & Ecology
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000810184200002
资助机构	National Natural Science Foundation of China ; Youth Innovation Promotion Association of CAS ; Anhui Provincial Key RD Programs ; Collaborative Innovation Program of Hefei Science Center, CAS ; Dean's Fund of Hefei Institute of Physical Science ; National Key R&D Program of China ; High Magnetic Field Laboratory of Anhui Province
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/131353]
专题	中国科学院合肥物质科学研究院
通讯作者	Zheng, Xinwei; Xu, An
作者单位	1.Chinese Acad Sci, High Magnet Field Lab, HFIPS, Hefei 230031, Anhui, Peoples R China 2.Chinese Acad Sci, Anhui Prov Key Lab Environm Toxicol & Pollut Contr, HFIPS, Hefei 230031, Anhui, Peoples R China 3.Shandong First Med Univ, Sch Publ Hlth, Tai'an, Peoples R China 4.Chinese Acad Sci, Anhui Prov Key Lab High Field Magnet Resonance Ima, HFIPS, Hefei 230031, Anhui, Peoples R China 5.Anhui Univ, Inst Phys Sci & Informat Technol, Hefei 230601, Anhui, Peoples R China 6.Chinese Acad Sci, High Magnet Field Lab, HFIPS, Hefei 230031, Anhui, Peoples R China 7.Shandong Acad Med Sci, Tai'an, Peoples R China
推荐引用方式 GB/T 7714	Liu, Yun,Wang, Xue,Si, Bo,et al. Zinc oxide/graphene oxide nanocomposites efficiently inhibited cadmium-induced hepatotoxicity via releasing Zn ions and up-regulating MRP1 expression[J]. ENVIRONMENT INTERNATIONAL,2022,165.
APA	Liu, Yun.,Wang, Xue.,Si, Bo.,Wang, Tong.,Wu, Yun.,...&Xu, An.(2022).Zinc oxide/graphene oxide nanocomposites efficiently inhibited cadmium-induced hepatotoxicity via releasing Zn ions and up-regulating MRP1 expression.ENVIRONMENT INTERNATIONAL,165.
MLA	Liu, Yun,et al."Zinc oxide/graphene oxide nanocomposites efficiently inhibited cadmium-induced hepatotoxicity via releasing Zn ions and up-regulating MRP1 expression".ENVIRONMENT INTERNATIONAL 165(2022).