Effects of N-6-Methyladenosine Modification on Cancer Progression: Molecular Mechanisms and Cancer Therapy

doi:10.3389/fonc.2022.897895

	Effects of N-6-Methyladenosine Modification on Cancer Progression: Molecular Mechanisms and Cancer Therapy
	Zhu, Yong-fu 1,2; Wang, Shu-Jie 3; Zhou, Jie 2; Sun, Ye-han 1; Chen, You-mou 1; Ma, Jia 1; Huo, Xing-xing 4; Song, Hang 5
刊名	FRONTIERS IN ONCOLOGY
	2022-05-30
卷号	12
关键词	RNA modifications N6-methyladenosine female malignancies molecular mechanisms immunotherapy
ISSN号	2234-943X
DOI	10.3389/fonc.2022.897895
通讯作者	Huo, Xing-xing(hxx0520@ahtcm.edu.cn) ; Song, Hang(hangsong@ahtcm.edu.cn)
英文摘要	N-6-methyladenosine (m(6)A) is a major internal epigenetic modification in eukaryotic mRNA, which is dynamic and reversible. m(6)A is regulated by methylases ("writers") and demethylases ("erasers") and is recognized and processed by m(6)A-binding proteins ("readers"), which further regulate RNA transport, localization, translation, and degradation. It plays a role in promoting or suppressing tumors and has the potential to become a therapeutic target for malignant tumors. In this review, we focus on the mutual regulation of m(6)A and coding and non-coding RNAs and introduce the molecular mechanism of m(6)A methylation involved in regulation and its role in cancer treatment by taking common female malignant tumors as an example.
资助项目	National Natural Science Foundation of China[81802103] ; National Natural Science Foundation of China[81803938] ; Project of High-Level Talents in AHUTCM[2019rcZD001] ; Excellent Young Scholars Project of Natural Science Foundation of Anhui Province in China[2108085Y29] ; Natural Science Research Project of Colleges and Universities in Anhui Province[KJ2021A0557] ; Opening Project of Zhejiang Provincial Preponderant and Characteristic Subject of Key University (Chinese Traditional Medicine) ; Zhejiang Chinese Medical University[ZYXZD2019004]
WOS关键词	INHIBITS CELL-PROLIFERATION ; CERVICAL-CANCER ; M(6)A MODIFICATION ; NONCODING RNAS ; METHYLATION ; TRANSLATION ; METASTASIS ; APOPTOSIS ; BINDING ; ROLES
WOS研究方向	Oncology
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000810217800001
资助机构	National Natural Science Foundation of China ; Project of High-Level Talents in AHUTCM ; Excellent Young Scholars Project of Natural Science Foundation of Anhui Province in China ; Natural Science Research Project of Colleges and Universities in Anhui Province ; Opening Project of Zhejiang Provincial Preponderant and Characteristic Subject of Key University (Chinese Traditional Medicine) ; Zhejiang Chinese Medical University
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/131321]
专题	中国科学院合肥物质科学研究院
通讯作者	Huo, Xing-xing; Song, Hang
作者单位	1.Anhui Univ Chinese Med, Dept Oncol 1, Affiliated Hosp 1, Hefei, Peoples R China 2.Zhejiang Chinese Med Univ, Dept Acupuncture, Affiliated Hosp 3, Hangzhou, Peoples R China 3.Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei, Peoples R China 4.Anhui Univ Chinese Med, Affiliated Hosp 1, Expt Ctr Clin Res, Sci Res Dept, Hefei, Peoples R China 5.Anhui Univ Chinese Med, Sch Integrated Chinese & Western Med, Dept Biochem & Mol Biol, Hefei, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Yong-fu,Wang, Shu-Jie,Zhou, Jie,et al. Effects of N-6-Methyladenosine Modification on Cancer Progression: Molecular Mechanisms and Cancer Therapy[J]. FRONTIERS IN ONCOLOGY,2022,12.
APA	Zhu, Yong-fu.,Wang, Shu-Jie.,Zhou, Jie.,Sun, Ye-han.,Chen, You-mou.,...&Song, Hang.(2022).Effects of N-6-Methyladenosine Modification on Cancer Progression: Molecular Mechanisms and Cancer Therapy.FRONTIERS IN ONCOLOGY,12.
MLA	Zhu, Yong-fu,et al."Effects of N-6-Methyladenosine Modification on Cancer Progression: Molecular Mechanisms and Cancer Therapy".FRONTIERS IN ONCOLOGY 12(2022).