Tumor-infiltrating lymphocytes-based subtypes and genomic characteristics of EBV-associated lymphoepithelioma-like carcinoma

doi:10.1002/path.5916

	Tumor-infiltrating lymphocytes-based subtypes and genomic characteristics of EBV-associated lymphoepithelioma-like carcinoma
	Yin, WenJuan 1,2; Jin, JiaoYue 1,2; Bao, Hua 4; Chen, HanLin 4; Wang, CanMing 1,2; Cheng, GuoPing 1,2; Wu, ChaoQi 1,2; Wu, Meijuan 1,2; Yan, Junrong 4; Wu, Xue 4
刊名	JOURNAL OF PATHOLOGY
	2022-05-20
关键词	lymphoepithelioma-like carcinomas TILs quantification classification whole exome sequencing targeted therapy
ISSN号	0022-3417
DOI	10.1002/path.5916
通讯作者	Su, Dan(sudan@zjcc.org.cn)
英文摘要	Tumor-infiltrating lymphocytes (TILs) offer a key for morphological diagnosis of lymphoepithelioma-like carcinoma (LELC) and are the foundation of oncoimmunology. To date, no reports have found a specific risk stratification value of TILs and related it to genomic variation in LELC. Based on the stromal TILs (str-TILs) ratio, we classified 105 Epstein-Barr virus (EBV)-associated LELC cases into two subtypes: patients with >= 60% str-TILs area ratio in tumor were classified as subtype I, and otherwise as subtype II. Subtype I patients had significantly better progression-free survival (PFS) and overall survival (OS). We also explored the genomic characteristics of EBV-associated LELC within different involved organs. We performed whole-exome sequencing for 51 patients with enough tissue and analyzed the genomic characteristics of EBV-associated LELC. Overall, EBV-associated LELCs were characterized by a low somatic mutation rate and copy number variations; the enriched genetic lesions affected RTK-RAS, PI3K, and cell cycle pathways. Moreover, EBV-associated LELCs from different organs were more similar to each other genetically as compared with other traditional carcinomas of the same sites?as evidenced by unsupervised clustering based on the quantitative data from both mutation signature and chromosomal aneuploidies. Notably, EBV-associated LELC patients with oncogenic driver alterations showed a worse prognosis compared with patients without such alterations. (c) 2022 The Pathological Society of Great Britain and Ireland.
资助项目	Key Research and Development Projects - Ministry of Science and Technology of Zhejiang Province[2020C03023] ; High-Level Creative and Innovative Health Talent Program of Zhejiang Province
WOS关键词	EPSTEIN-BARR-VIRUS ; EXPRESSION
WOS研究方向	Oncology ; Pathology
语种	英语
出版者	WILEY
WOS记录号	WOS:000799491800001
资助机构	Key Research and Development Projects - Ministry of Science and Technology of Zhejiang Province ; High-Level Creative and Innovative Health Talent Program of Zhejiang Province
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/131063]
专题	中国科学院合肥物质科学研究院
通讯作者	Su, Dan
作者单位	1.Chinese Acad Sci, Inst Basic Med & Canc IBMC, Hangzhou, Peoples R China 2.Univ Chinese Acad Sci, Canc Hosp, Dept Pathol, Zhejiang Canc Hosp, Hangzhou, Peoples R China 3.Nanjing Med Univ, Sch Publ Hlth, Nanjing, Peoples R China 4.Nanjing Geneseeq Technol Inc, Nanjing, Peoples R China
推荐引用方式 GB/T 7714	Yin, WenJuan,Jin, JiaoYue,Bao, Hua,et al. Tumor-infiltrating lymphocytes-based subtypes and genomic characteristics of EBV-associated lymphoepithelioma-like carcinoma[J]. JOURNAL OF PATHOLOGY,2022.
APA	Yin, WenJuan.,Jin, JiaoYue.,Bao, Hua.,Chen, HanLin.,Wang, CanMing.,...&Su, Dan.(2022).Tumor-infiltrating lymphocytes-based subtypes and genomic characteristics of EBV-associated lymphoepithelioma-like carcinoma.JOURNAL OF PATHOLOGY.
MLA	Yin, WenJuan,et al."Tumor-infiltrating lymphocytes-based subtypes and genomic characteristics of EBV-associated lymphoepithelioma-like carcinoma".JOURNAL OF PATHOLOGY (2022).