Pulmonary Epithelial-Myoepithelial Carcinoma

doi:10.1155/2022/4559550

	Pulmonary Epithelial-Myoepithelial Carcinoma
	Chen, Lingru 1,2,3,4; Fan, Ying 1,2,3,4; Lu, Hongyang 1,2,3,4
刊名	JOURNAL OF ONCOLOGY
	2022-10-11
卷号	2022
ISSN号	1687-8450
DOI	10.1155/2022/4559550
通讯作者	Lu, Hongyang(luhy@zjcc.org.cn)
英文摘要	Pulmonary epithelial-myoepithelial carcinoma (P-EMC) is an exceptionally rare subtype of salivary gland lung tumor originating from tracheobronchial glands. P-EMC is a biphasic tumor consisting of an inner layer of epithelial cells and an outer layer of spindle-shaped, clear-cell-like myoepithelial cells. Bronchial obstruction symptom is the main clinical characteristic for P-EMC. Because its clinical and imaging characteristics are highly similar to other types of non-small-cell lung cancer (NSCLC), it is easy to cause missed diagnosis and misdiagnosis. The diagnosis is mainly based on the pathology and immunohistochemistry with an inner layer of epithelial cells immunoreactive for cytokeratin and an outside layer of myoepithelial cells immunoreactive for S100 protein (S-100) and smooth muscle actin (SMA). Therefore, positive for cytokeratin, S-100 and SMA can assist in the diagnosis. Although in general, P-EMC is a low-grade malignant neoplasm, it may occasionally recur and metastasize. The optimal method for P-EMC treatment has not been established, and surgical resection is still the main clinical method. Radiotherapy and chemotherapy have been shown not sensitive for P-EMC treatment, whereas targeted therapy and immunotherapy have not evaluated in clinical practice. This review focuses on the pathological characteristics, molecular characteristics, diagnosis, treatment, and prognosis of P-EMC.
资助项目	Zhejiang Province Medical Science and Technology Project ; [2020ZH001]
WOS关键词	GLAND-TYPE TUMORS ; LUNG-CANCER ; SALIVARY ; ADENOMYOEPITHELIOMA ; METASTASES
WOS研究方向	Oncology
语种	英语
出版者	HINDAWI LTD
WOS记录号	WOS:000876503600001
资助机构	Zhejiang Province Medical Science and Technology Project
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/130162]
专题	中国科学院合肥物质科学研究院
通讯作者	Lu, Hongyang
作者单位	1.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Zhejiang Key Lab Diag & Treatment Technol Thorac, Hangzhou 310022, Peoples R China 2.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Thorac Med Oncol, Hangzhou 310022, Peoples R China 3.Chinese Acad Sci, Inst Basic Med & Canc IBMC, Hangzhou 310022, Peoples R China 4.Wenzhou Med Univ, Wenzhou 325035, Peoples R China
推荐引用方式 GB/T 7714	Chen, Lingru,Fan, Ying,Lu, Hongyang. Pulmonary Epithelial-Myoepithelial Carcinoma[J]. JOURNAL OF ONCOLOGY,2022,2022.
APA	Chen, Lingru,Fan, Ying,&Lu, Hongyang.(2022).Pulmonary Epithelial-Myoepithelial Carcinoma.JOURNAL OF ONCOLOGY,2022.
MLA	Chen, Lingru,et al."Pulmonary Epithelial-Myoepithelial Carcinoma".JOURNAL OF ONCOLOGY 2022(2022).