Hypoxia-inducible factor 1-alpha is a driving mechanism linking chronic obstructive pulmonary disease to lung cancer

doi:10.3389/fonc.2022.984525

	Hypoxia-inducible factor 1-alpha is a driving mechanism linking chronic obstructive pulmonary disease to lung cancer
	Xu, Yuan-rui 1,2; Wang, An-long 1; Li, Ya-qing 1
刊名	FRONTIERS IN ONCOLOGY
	2022-10-21
卷号	12
关键词	chronic obstructive pulmonary disease lung cancer non-small cell lung cancer hypoxia-inducible factor 1-alpha hypoxia-inducible factor 1
ISSN号	2234-943X
DOI	10.3389/fonc.2022.984525
通讯作者	Li, Ya-qing(lidoctor03@126.com)
英文摘要	Patients with chronic obstructive pulmonary disease (COPD), irrespective of their smoking history, are more likely to develop lung cancer than the general population. This is mainly because COPD is characterized by chronic persistent inflammation and hypoxia, which are the risk factors for lung cancer. However, the mechanisms underlying this observation are still unknown. Hypoxia-inducible factor 1-alpha (HIF-1 alpha) plays an important role in the crosstalk that exists between inflammation and hypoxia. Furthermore, HIF-1 alpha is the main regulator of somatic adaptation to hypoxia and is highly expressed in hypoxic environments. In this review, we discuss the molecular aspects of the crosstalk between hypoxia and inflammation, showing that HIF-1 alpha is an important signaling pathway that drives COPD progression to lung cancer. Here, we also provide an overview of HIF-1 alpha and its principal regulatory mechanisms, briefly describe HIF-1 alpha-targeted therapy in lung cancer, and summarize substances that may be used to target HIF-1 alpha at the level of COPD-induced inflammation.
资助项目	National Natural Science Foundation of China ; Zhejiang Provincial Program for the Cultivation of High-level Innovative Health Talents ; [81870028] ; [81470241] ; [A-2017-CXCR02]
WOS关键词	TUMOR-GROWTH ; KAPPA-B ; TRANSCRIPTIONAL ACTIVITY ; DIRECT PHOSPHORYLATION ; SIRTUIN 1 ; HIF-1-ALPHA ; EXPRESSION ; COPD ; ANGIOGENESIS ; SUPPRESSES
WOS研究方向	Oncology
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000879238600001
资助机构	National Natural Science Foundation of China ; Zhejiang Provincial Program for the Cultivation of High-level Innovative Health Talents
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/130134]
专题	中国科学院合肥物质科学研究院
通讯作者	Li, Ya-qing
作者单位	1.Univ Chinese Acad Sci, Canc Hosp, Zhejiang Canc Hosp, Hangzhou, Zhejiang, Peoples R China 2.Zhejiang Chinese Med Univ, Clin Med Coll 2, Hangzhou, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Xu, Yuan-rui,Wang, An-long,Li, Ya-qing. Hypoxia-inducible factor 1-alpha is a driving mechanism linking chronic obstructive pulmonary disease to lung cancer[J]. FRONTIERS IN ONCOLOGY,2022,12.
APA	Xu, Yuan-rui,Wang, An-long,&Li, Ya-qing.(2022).Hypoxia-inducible factor 1-alpha is a driving mechanism linking chronic obstructive pulmonary disease to lung cancer.FRONTIERS IN ONCOLOGY,12.
MLA	Xu, Yuan-rui,et al."Hypoxia-inducible factor 1-alpha is a driving mechanism linking chronic obstructive pulmonary disease to lung cancer".FRONTIERS IN ONCOLOGY 12(2022).