Cold Atmospheric Plasma Inhibits the Proliferation of CAL-62 Cells through the ROS-Mediated PI3K/Akt/mTOR Signaling Pathway

doi:10.1155/2022/3884695

	Cold Atmospheric Plasma Inhibits the Proliferation of CAL-62 Cells through the ROS-Mediated PI3K/Akt/mTOR Signaling Pathway
	Liu, Fang 1,2; Zhou, Yuanyuan 1,2; Song, Wencheng 2,3; Wang, Hongzhi 2,3
刊名	SCIENCE AND TECHNOLOGY OF NUCLEAR INSTALLATIONS
	2022-06-08
卷号	2022
ISSN号	1687-6075
DOI	10.1155/2022/3884695
通讯作者	Song, Wencheng(wencsong@cmpt.ac.cn) ; Wang, Hongzhi(wanghz@hfcas.ac.cn)
英文摘要	This study aimed to investigate the inhibitory effects of cold atmospheric plasma (CAP) on anaplastic thyroid cancer cells (CAL-62 cells) and to reveal the molecular mechanism. The effects of CAP on CAL-62 cells were evaluated by cell viability, superoxide dismutase activity, apoptosis, cell cycle, and protein expression level, and the role of reactive oxygen species (ROS) produced by plasma was also investigated. The results showed that CAP dose-dependently inhibited cell viability and promotes cell apoptosis and G2/M arrest by increasing cell ROS levels. The activity of superoxide dismutase (SOD) was enhanced by CAP which indicated that the antioxidant system of the cell was activated. Additionally, the ROS produced by CAP can inhibit CAL-62 cell proliferation by inhibiting the PI3K/Akt/mTOR signaling pathway. Therefore, these findings will provide useful support for the application of CAP for treating anaplastic thyroid cancer.
资助项目	National Natural Science Foundation of China[21876179] ; National Natural Science Foundation of China[22142007]
WOS关键词	APOPTOSIS ; SENSITIVITY ; INVOLVEMENT ; SYSTEM ; INJURY
WOS研究方向	Nuclear Science & Technology
语种	英语
出版者	HINDAWI LTD
WOS记录号	WOS:000813590800001
资助机构	National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/129574]
专题	中国科学院合肥物质科学研究院
通讯作者	Song, Wencheng; Wang, Hongzhi
作者单位	1.Anhui Univ, Inst Phys Sci & Informat Technol, Hefei 230601, Peoples R China 2.Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R China 3.Chinese Acad Sci, Hefei Canc Hosp, Hefei 230031, Peoples R China
推荐引用方式 GB/T 7714	Liu, Fang,Zhou, Yuanyuan,Song, Wencheng,et al. Cold Atmospheric Plasma Inhibits the Proliferation of CAL-62 Cells through the ROS-Mediated PI3K/Akt/mTOR Signaling Pathway[J]. SCIENCE AND TECHNOLOGY OF NUCLEAR INSTALLATIONS,2022,2022.
APA	Liu, Fang,Zhou, Yuanyuan,Song, Wencheng,&Wang, Hongzhi.(2022).Cold Atmospheric Plasma Inhibits the Proliferation of CAL-62 Cells through the ROS-Mediated PI3K/Akt/mTOR Signaling Pathway.SCIENCE AND TECHNOLOGY OF NUCLEAR INSTALLATIONS,2022.
MLA	Liu, Fang,et al."Cold Atmospheric Plasma Inhibits the Proliferation of CAL-62 Cells through the ROS-Mediated PI3K/Akt/mTOR Signaling Pathway".SCIENCE AND TECHNOLOGY OF NUCLEAR INSTALLATIONS 2022(2022).