Baseline anemia predicts a poor prognosis in patients with non-small cell lung cancer with epidermal growth factor receptor mutations: a retrospective study

doi:10.1186/s12890-022-02158-w

	Baseline anemia predicts a poor prognosis in patients with non-small cell lung cancer with epidermal growth factor receptor mutations: a retrospective study
	Wei, Jingwen 2,3; Xiang, Jing 2,4; Hao, Yue 2,4; Si, Jinfei 2,4; Wang, Wenxian 5; Li, Fangyin 1; Song, Zhengbo 2
刊名	BMC PULMONARY MEDICINE
	2022-10-17
卷号	22
关键词	Anemia Epidermal growth factor receptor Epidermal growth factor receptor tyrosine kinase inhibitors Non-small cell lung cancer
ISSN号	1471-2466
DOI	10.1186/s12890-022-02158-w
通讯作者	Li, Fangyin(lify824@126.com) ; Song, Zhengbo(songzb@zjcc.org.cn)
英文摘要	Background Anemia is relatively common in cancer patients, and baseline anemia is associated with poor survival in patients with non-small cell lung cancer (NSCLC). However, there is a lack of large-sample studies of patients with NSCLC with epidermal growth factor receptor (EGFR) mutations. Methods We retrospectively analyzed anemia-related data for patients with NSCLC and EGFR mutations who were admitted to Zhejiang Cancer Hospital from January 2013 to June 2019 and treated with targeted therapy. The patients' clinicopathological features were evaluated by chi(2) tests and the relationships between clinical characteristics and prognosis were investigated using Kaplan-Meier and multivariate Cox regression analyses. Results A total of 2,029 patients treated with EGFR-tyrosine kinase inhibitors (TKIs) were finally enrolled in this study, of whom 24.6% had baseline anemia. Patients without baseline anemia had longer median overall survival (OS) than patients with baseline anemia (36.10 vs. 29.10 months, P = 0.001), and patients with grade < 2 anemia had longer median OS than those with grade >= 2 anemia (35.00 vs. 25.10 months, P < 0.001). Multivariate analyses identified baseline anemia as a factor predicting a poor prognosis in terms of OS in patients with EGFR mutations. Conclusions Baseline anemia is a significant factor predicting a poor prognosis in terms of OS in patients with NSCLC and EGFR mutations treated with targeted therapy. A higher grade of baseline anemia may also be related to shorter OS. And a higher risk of EGFR-mutated patients who had received targeted therapy could also be observed.
资助项目	Medical Scientific Research Foundation of Zhejiang Province[2022KY653]
WOS关键词	HEALTH-ORGANIZATION CLASSIFICATION ; SURVIVAL ; TUMOR ; EPIDEMIOLOGY ; INFLAMMATION ; EXPRESSION ; CARCINOMA ; HYPOXIA ; IMPACT ; IRON
WOS研究方向	Respiratory System
语种	英语
出版者	BMC
WOS记录号	WOS:000869249500001
资助机构	Medical Scientific Research Foundation of Zhejiang Province
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/129474]
专题	中国科学院合肥物质科学研究院
通讯作者	Li, Fangyin; Song, Zhengbo
作者单位	1.Univ Chinese Acad Sci, Canc Hosp, Zhejiang Canc Hosp, Dept Urol, 1 Banshan East Rd, Hangzhou 310022, Peoples R China 2.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Clin Trial, 1 Banshan East Rd, Hangzhou 310022, Peoples R China 3.Wenzhou Med Univ, Wenzhou, Peoples R China 4.Chinese Med Univ, Clin Med Coll Zhejiang 2, Hangzhou, Peoples R China 5.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Med Oncol, Hangzhou, Peoples R China
推荐引用方式 GB/T 7714	Wei, Jingwen,Xiang, Jing,Hao, Yue,et al. Baseline anemia predicts a poor prognosis in patients with non-small cell lung cancer with epidermal growth factor receptor mutations: a retrospective study[J]. BMC PULMONARY MEDICINE,2022,22.
APA	Wei, Jingwen.,Xiang, Jing.,Hao, Yue.,Si, Jinfei.,Wang, Wenxian.,...&Song, Zhengbo.(2022).Baseline anemia predicts a poor prognosis in patients with non-small cell lung cancer with epidermal growth factor receptor mutations: a retrospective study.BMC PULMONARY MEDICINE,22.
MLA	Wei, Jingwen,et al."Baseline anemia predicts a poor prognosis in patients with non-small cell lung cancer with epidermal growth factor receptor mutations: a retrospective study".BMC PULMONARY MEDICINE 22(2022).