PDGF-B conjugating mesoporous IO/GdO nanocomposites for accurate diagnosis of orthotopic prostatic cancer through T-1-T-2 dual-modal MRI contrast enhancement

doi:10.1016/j.mtadv.2022.100278

	PDGF-B conjugating mesoporous IO/GdO nanocomposites for accurate diagnosis of orthotopic prostatic cancer through T-1-T-2 dual-modal MRI contrast enhancement
	Li, Qingdong 2; Xiao, Jianmin 2; Zhang, Caiyun 2; Wang, Peng 2; Li, Wenling 2; Wang, Yinfeng 2; Ran, Lang 2; Qin, Xia 2; Yan, Miao 3; Qian, Junchao 1
刊名	MATERIALS TODAY ADVANCES
	2022-12-01
卷号	16
关键词	IO GdO nanocomposite T1 T2 dual modal MRI Orthotopic prostate cancer Accurate diagnosis
ISSN号	2590-0498
DOI	10.1016/j.mtadv.2022.100278
通讯作者	Tian, Geng(tiangengbmu@163.com) ; Wei, Pengfei(pfwei@bzmc.edu.cn) ; Zhang, Guilong(glzhang@bzmc.edu.cn)
英文摘要	The development of highly efficient magnetic resonance imaging (MRI) contrast agent contributes to the early and accurate diagnosis of cancer. Herein, we developed a novel iron oxide and gadolinium oxide (IO/GdO) nanocomposite as T-1-T-2 dual modal MRI contrast agent through hydrothermal synthesis method. Subsequently, tumor-targeting ligand (PDGFB-PEG) was further conjugated to the surface of IO/ GdO nanocomposite (PDGFB-pIO/GdO) to fabricate tumor-targeting MRI probe for accurate diagnosis of orthotopic prostatic cancer. IO/GdO nanocomposite exhibited obvious mesoporous structure, which would promote the contact between water molecules and Gd or Fe centers and enhance the T(1 )relaxation rate (r(1)) and T-2 relaxation rate (r(2)) of IO/GdO composite. In addition, the r1 and r2 values of IO/GdO composite were up to be 11.6 mM(-1)s(-1) and 102.7 mM(-1)s(-1), respectively, and the r(2)/r(1) ratio of IO/GdO nanocomposite was calculated to be 8.85, demonstrating a great potential as dual-mode MRI contrast agent. Further study indicated that PDGFB-pIO/GdO exhibited an excellent biocompatibility. Besides, PDGFB-pIO/GdO presented a higher accumulation in tumor than untargeted pIO/GdO, confirming its excellent in vivo tumor-targeting ability. Lastly, in orthotopic prostatic cancer model, the systemic de-livery of PDGFB-pIO/GdO significantly enhanced T-1- and T-2-weighted signal of orthotopic prostatic cancer, achieving high quality of MR images and realizing accurate diagnosis of orthotopic prostatic cancer. Collectively, we proposed a rational designed nanoplatform, PDGF-B conjugating mesoporous IO/ GdO nanocomposites, suggesting potential for diagnostic identification of prostate cancer via T-1-T-2 dual -modal MRI contrast enhancement.(c) 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
资助项目	National Natural Science Foundation of China[22007006] ; National Natural Science Foundation of China[31771284] ; Taishan Scholars Construction Engineering[tsqn20161047] ; Taishan Scholars Construction Engineering[tsqn201909144] ; Taishan Scholars Construction Engineering[tsqn202103112] ; Special Project of Cenral Government for Local Science and Technology Development of Shandong Province, China[YDZX20203700001291] ; support plan for youth entrepreneurship and technology of colleges and universities in Shandong Province, China[2021KJ052]
WOS关键词	IRON-OXIDE NANOPROBE ; T-1 ; NANOPARTICLES ; AGENTS ; NANOCUBES ; BLOOD ; T1
WOS研究方向	Materials Science
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000860494200009
资助机构	National Natural Science Foundation of China ; Taishan Scholars Construction Engineering ; Special Project of Cenral Government for Local Science and Technology Development of Shandong Province, China ; support plan for youth entrepreneurship and technology of colleges and universities in Shandong Province, China
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/129161]
专题	中国科学院合肥物质科学研究院
通讯作者	Tian, Geng; Wei, Pengfei; Zhang, Guilong
作者单位	1.Chinese Acad Sci, Hefei Canc Hosp, Inst Hlth & Med Technol, Hefei Inst Phys Sci,Anhui Prov Key Lab Med Phys &, Hefei 230031, Peoples R China 2.Binzhou Med Univ, Shandong Technol Innovat Ctr Mol Targeting & Intel, Sch Pharm, Yantai 264003, Peoples R China 3.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Peoples R China
推荐引用方式 GB/T 7714	Li, Qingdong,Xiao, Jianmin,Zhang, Caiyun,et al. PDGF-B conjugating mesoporous IO/GdO nanocomposites for accurate diagnosis of orthotopic prostatic cancer through T-1-T-2 dual-modal MRI contrast enhancement[J]. MATERIALS TODAY ADVANCES,2022,16.
APA	Li, Qingdong.,Xiao, Jianmin.,Zhang, Caiyun.,Wang, Peng.,Li, Wenling.,...&Zhang, Guilong.(2022).PDGF-B conjugating mesoporous IO/GdO nanocomposites for accurate diagnosis of orthotopic prostatic cancer through T-1-T-2 dual-modal MRI contrast enhancement.MATERIALS TODAY ADVANCES,16.
MLA	Li, Qingdong,et al."PDGF-B conjugating mesoporous IO/GdO nanocomposites for accurate diagnosis of orthotopic prostatic cancer through T-1-T-2 dual-modal MRI contrast enhancement".MATERIALS TODAY ADVANCES 16(2022).