9.4 T static magnetic field ameliorates imatinib mesylate-induced toxicity and depression in mice

doi:10.1007/s00259-022-05976-6

	9.4 T static magnetic field ameliorates imatinib mesylate-induced toxicity and depression in mice
	Tian, Xiaofei 3,4; Wang, Chentai 3,4; Yu, Biao 5; Fan, Yixiang 1,5; Zhang, Lei 5; Zhang, Xin 1,2,3,4,5
刊名	EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
	2022-09-27
关键词	Static magnetic fields (SMFs) Imatinib mesylate Gastrointestinal stromal tumor (GIST) Drug toxicity Depression
ISSN号	1619-7070
DOI	10.1007/s00259-022-05976-6
通讯作者	Zhang, Lei(leizhang@hmfl.ac.cn) ; Zhang, Xin(xinzhang@hmfl.ac.cn)
英文摘要	Purpose 9.4 T magnetic resonance imaging (MRI) has been initially tested on healthy human volunteers, but its future application will benefit more from experiments with animal disease models. In the meantime, high static magnetic fields (SMFs) have been shown to improve mice mental health and have anti-tumor potentials. Methods We compared the anti-tumor effects of 9.4 T SMF with or without a commonly used chemotherapy drug imatinib mesylate on BALB/c (Nu/Nu) mice bearing gastrointestinal stromal tumor GIST-T1 cells. The body weight, food/water consumption, complete blood count, blood biochemistry, tumor weight, HE and Ki67 stains were examined. Locomotor activity and cognitive functions were also measured by four behavior tests, including open field, elevated plus maze, three-chamber and tail suspension tests. Results We found that the tumor growth was inhibited up to 62.88% when treated with 9.4 T SMF alone for 200 h. More importantly, 9.4 T SMF combined with 20 mg/kg imatinib mesylate can result in 92.75% tumor suppression, which is close to the anti-tumor effect of high dose (80 mg/kg) imatinib. However, 80 mg/kg imatinib caused severe side effects, including significantly reduced gain of body weight, abnormal liver function and depressive behaviors in mice. In contrast, 9.4 T SMF treatment significantly reduced these side effects, especially for the depressive behaviors. Conclusion Our results demonstrate that 9.4 T SMF not only has anti-tumor effects on its own, but also could improve the anti-tumor effect of imatinib mesylate, reduce its toxicity and improve the mice mental health, which unraveled the great clinical potentials of high SMF in future applications.
资助项目	High Magnetic Field Laboratory Facility, Chinese Academy of Sciences
WOS关键词	GASTROINTESTINAL STROMAL TUMORS ; BEHAVIOR ; MRI ; INHIBITOR ; EFFICACY ; ANXIETY ; SODIUM ; SAFETY ; BRAIN
WOS研究方向	Radiology, Nuclear Medicine & Medical Imaging
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000860408100003
资助机构	High Magnetic Field Laboratory Facility, Chinese Academy of Sciences
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/129157]
专题	中国科学院合肥物质科学研究院
通讯作者	Zhang, Lei; Zhang, Xin
作者单位	1.Univ Sci & Technol China, Grad Sch, Sci Isl Branch, Hefei 230021, Anhui, Peoples R China 2.Int Magnetobiol Frontier Res Ctr, Hefei 230036, Anhui, Peoples R China 3.Anhui Univ, Inst Phys Sci, Hefei 230601, Anhui, Peoples R China 4.Anhui Univ, Inst Informat Technol, Hefei 230601, Anhui, Peoples R China 5.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, Key Lab High Magnet Field & Ion Beam Phys Biol, Shushanhu Rd 350, Hefei 230031, Anhui, Peoples R China
推荐引用方式 GB/T 7714	Tian, Xiaofei,Wang, Chentai,Yu, Biao,et al. 9.4 T static magnetic field ameliorates imatinib mesylate-induced toxicity and depression in mice[J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING,2022.
APA	Tian, Xiaofei,Wang, Chentai,Yu, Biao,Fan, Yixiang,Zhang, Lei,&Zhang, Xin.(2022).9.4 T static magnetic field ameliorates imatinib mesylate-induced toxicity and depression in mice.EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING.
MLA	Tian, Xiaofei,et al."9.4 T static magnetic field ameliorates imatinib mesylate-induced toxicity and depression in mice".EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2022).