Increased Sensitivity in Proton Transfer Reaction Mass Spectrometry by Using a Novel Focusing Quadrupole Ion Funnel

doi:10.1021/acs.analchem.2c01893

	Increased Sensitivity in Proton Transfer Reaction Mass Spectrometry by Using a Novel Focusing Quadrupole Ion Funnel
	Bao, Xun 1,2; Zhang, Qiangling 2; Liang, Qu 1,2; Sun, Qin 1,2; Xu, Wei 1,2; Lu, Yan 2; Xia, Lei 2; Liu, Yawei 2; Zou, Xue 2; Huang, Chaoqun 2
刊名	ANALYTICAL CHEMISTRY
	2022-09-23
ISSN号	0003-2700
DOI	10.1021/acs.analchem.2c01893
通讯作者	Zhang, Qiangling(qlzhang@cmpt.ac.cn) ; Shen, Chengyin(chyshen@aiofm.ac.cn)
英文摘要	Sensitivity enhancement in proton transfer reaction mass spectrometry (PTR-MS) is an important development direction. We developed a novel drift tube called a focusing quadrupole ion funnel (FQ-IF) for use in PTR-MS to improve the sensitivity. The FQ-IF consists of 20 layers of stainless steel electrodes, and each layer has 4 quarter rings. The first 6 layers have a constant inner hole diameter of 22 mm; the latter 14 layers taper the inner diameter down to 8 mm. The FQ-IF drift tube can also operate in the direct current (DC) mode (similar to a conventional drift tube) and ion funnel (IF) mode (similar to a conventional ion funnel drift tube) by changing the voltage loading method. The simulation results show that the transmission efficiency of the FQ-IF is significantly improved compared to that of the other two modes. Further experiments show that the product ions of limonene tend to convert into smaller m/z fragment ions at higher voltages for the DC and IF modes. However, unlike the DC and IF modes, the distribution of product ions is stable at higher voltages for the FQ-IF. In other words, a higher RF voltage for the FQ-IF will not increase the collision energy of ions. In addition, the improvements in sensitivity for the FQ-IF range from 13.8 to 87.9 times compared to the DC mode and from 1.7 to 4.8 times compared to the IF mode for the 12 test compounds. The improvements in the limit of detection (LOD) for the FQ-IF range from 2.7 to 35.7 times compared to the DC mode. The FQ-IF provides a valuable reference for improving the sensitivity of PTR-MS and other mass spectrometers.
资助项目	National Natural Science Foundation of China[22076190] ; National Natural Science Foundation of China[21876176] ; National Natural Science Foundation of China[21777163] ; National Natural Science Foundation of China[21705152] ; National Natural Science Foundation of China[62171433] ; Youth Innovation Promotion Association, CAS, China[2019432] ; HFIPS Director's Fund[BJPY2021B08] ; HFIPS Director's Fund[YZJJ2022QN45] ; HFIPS Director's Fund[YZJJZX202009] ; Second Affiliated Hospital of Anhui Medical University[LHJJ2020006] ; Center of Medical Physics and Technology of the Hefei Institute of Physical Sciences of the Chinese Academy of Sciences[LHJJ2020006] ; Anhui Provincial Key RD Program[202104d07020003]
WOS关键词	VOLATILE ORGANIC-COMPOUNDS ; PTR-MS ; HUMIDITY-DEPENDENCE ; AIR
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000861738700001
资助机构	National Natural Science Foundation of China ; Youth Innovation Promotion Association, CAS, China ; HFIPS Director's Fund ; Second Affiliated Hospital of Anhui Medical University ; Center of Medical Physics and Technology of the Hefei Institute of Physical Sciences of the Chinese Academy of Sciences ; Anhui Provincial Key RD Program
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/129093]
专题	中国科学院合肥物质科学研究院
通讯作者	Zhang, Qiangling; Shen, Chengyin
作者单位	1.Univ Sci & Technol China, Hefei 230026, Peoples R China 2.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Hlth & Med Technol, Anhui Prov Key Lab Med Phys & Technol, R China, Hefei 230031, Peoples R China 3.Chinese Acad Sci, Hefei Canc Hosp, Hefei 230031, Peoples R China
推荐引用方式 GB/T 7714	Bao, Xun,Zhang, Qiangling,Liang, Qu,et al. Increased Sensitivity in Proton Transfer Reaction Mass Spectrometry by Using a Novel Focusing Quadrupole Ion Funnel[J]. ANALYTICAL CHEMISTRY,2022.
APA	Bao, Xun.,Zhang, Qiangling.,Liang, Qu.,Sun, Qin.,Xu, Wei.,...&Chu, Yannan.(2022).Increased Sensitivity in Proton Transfer Reaction Mass Spectrometry by Using a Novel Focusing Quadrupole Ion Funnel.ANALYTICAL CHEMISTRY.
MLA	Bao, Xun,et al."Increased Sensitivity in Proton Transfer Reaction Mass Spectrometry by Using a Novel Focusing Quadrupole Ion Funnel".ANALYTICAL CHEMISTRY (2022).