Self-assembled Pt(II) metallacycles enable precise cancer combination chemotherapy | |
Zhang, Pengge1; Zhou, Zhixuan2; Long, Wen3; Yan, Yuping1; Li, Youshan1; Fu, Ting1,4; Liu, Yanlan1; Zhao, Zilong1; Tan, Weihong1,4,5,6; Stang, Peter J.2 | |
刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA |
2022-05-17 | |
卷号 | 119 |
关键词 | self-assembly supramolecular coordination complex combination chemotherapy targeted cancer therapy drug delivery |
ISSN号 | 0027-8424 |
DOI | 10.1073/pnas.2202255119 |
通讯作者 | Zhao, Zilong(zlzhao@hnu.edu.cn) ; Tan, Weihong(tan@hnu.edu.cn) ; Stang, Peter J.(stang@chem.utah.edu) |
英文摘要 | Combination chemotherapy, which involves the simultaneous use of multiple anticancer drugs in adequate combinations to disrupt multiple mechanisms associated with tumor growth, has shown advantages in enhanced therapeutic efficacy and lower systemic toxicity relative to monotherapy. Herein, we employed coordination-driven self-assembly to construct discrete Pt(II) metallacycles as monodisperse, modular platforms for combining camptothecin and combretastatin A4, two chemotherapy agents with a disparate mechanism of action, in precise arrangements for combination chemotherapy. Formulation of the drug-loaded metallacycles with folic acid-functionalized amphiphilic diblock copolymers furnished nanoparticles with good solubility and stability in physiological conditions. Folic acids on the surface of the nanoparticles promote their internalization into cancer cells. The intracellular reductive environment of cancer cells induces the release of the drug molecules at an exact 1:1 ratio, leading to a synergistic anticancer efficacy. In vivo studies on tumor-bearing mice demonstrated the favorable therapeutic outcome and minimal side effects of the combination chemotherapy approach based on a self-assembled metallacycle. |
资助项目 | National Key Research and Development Program[2021YFA0910000] ; National Natural Science Foundation of China[21974040] ; National Natural Science Foundation of China[22177028] |
WOS关键词 | DRUG ; CAGES ; FUNCTIONALIZATION ; FLUORESCENCE ; METALLACAGES ; DELIVERY ; PRODRUG |
WOS研究方向 | Science & Technology - Other Topics |
语种 | 英语 |
出版者 | NATL ACAD SCIENCES |
WOS记录号 | WOS:000854008900012 |
资助机构 | National Key Research and Development Program ; National Natural Science Foundation of China |
内容类型 | 期刊论文 |
源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/128998] |
专题 | 中国科学院合肥物质科学研究院 |
通讯作者 | Zhao, Zilong; Tan, Weihong; Stang, Peter J. |
作者单位 | 1.Hunan Univ, Coll Chem & Chem Engn, Aptamer Engn Ctr Hunan Prov, Mol Sci & Biomed Lab MBL,State Key Lab Chemo Bios, Changsha 410082, Peoples R China 2.Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA 3.Hunan Normal Univ, Dept Chem & Chem Engn, Changsha 410081, Peoples R China 4.Chinese Acad Sci, Zhejiang Canc Hosp, Univ Chinese Acad Sci, Canc Hosp,Hangzhou Inst Med HIM, Hangzhou 310022, Peoples R China 5.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Inst Mol Med IMM, Shanghai 200240, Peoples R China 6.Shanghai Jiao Tong Univ, Coll Chem & Chem Engn, Shanghai 200240, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, Pengge,Zhou, Zhixuan,Long, Wen,et al. Self-assembled Pt(II) metallacycles enable precise cancer combination chemotherapy[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2022,119. |
APA | Zhang, Pengge.,Zhou, Zhixuan.,Long, Wen.,Yan, Yuping.,Li, Youshan.,...&Stang, Peter J..(2022).Self-assembled Pt(II) metallacycles enable precise cancer combination chemotherapy.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,119. |
MLA | Zhang, Pengge,et al."Self-assembled Pt(II) metallacycles enable precise cancer combination chemotherapy".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 119(2022). |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论