Highly hydrated paramagnetic amorphous calcium carbonate nanoclusters as an MRI contrast agent

doi:10.1038/s41467-022-32615-3

	Highly hydrated paramagnetic amorphous calcium carbonate nanoclusters as an MRI contrast agent
	Dong, Liang 1,2,3; Xu, Yun-Jun 4; Sui, Cong 1; Zhao, Yang 1; Mao, Li-Bo 1; Gebauer, Denis 5; Rosenberg, Rose 6; Avaro, Jonathan 7; Wu, Ya-Dong 3; Gao, Huai-Ling 1
刊名	NATURE COMMUNICATIONS
	2022-08-29
卷号	13
DOI	10.1038/s41467-022-32615-3
通讯作者	Lu, Yang(yanglu@hfut.edu.cn) ; Colfen, Helmut(helmut.coelfen@uni-konstanz.de) ; Yu, Shu-Hong(shyu@ustc.edu.cn)
英文摘要	Sensitive, biocompatible and stable contrast agents for MRI are in demand. Here, the authors combine gadolinium ions with amorphous calcium carbonate to make stable paramagnetic amorphous carbonate nanoclusters with high MRI contrast and significantly improved biocompatibility over commercial gadolinium-based agents. Amorphous calcium carbonate plays a key role as transient precursor in the early stages of biogenic calcium carbonate formation in nature. However, due to its instability in aqueous solution, there is still rare success to utilize amorphous calcium carbonate in biomedicine. Here, we report the mutual effect between paramagnetic gadolinium ions and amorphous calcium carbonate, resulting in ultrafine paramagnetic amorphous carbonate nanoclusters in the presence of both gadolinium occluded highly hydrated carbonate-like environment and poly(acrylic acid). Gadolinium is confirmed to enhance the water content in amorphous calcium carbonate, and the high water content of amorphous carbonate nanoclusters contributes to the much enhanced magnetic resonance imaging contrast efficiency compared with commercially available gadolinium-based contrast agents. Furthermore, the enhanced T-1 weighted magnetic resonance imaging performance and biocompatibility of amorphous carbonate nanoclusters are further evaluated in various animals including rat, rabbit and beagle dog, in combination with promising safety in vivo. Overall, exceptionally facile mass-productive amorphous carbonate nanoclusters exhibit superb imaging performance and impressive stability, which provides a promising strategy to design magnetic resonance contrast agent.
资助项目	National Natural Science Foundation of China[51732011] ; National Natural Science Foundation of China[U1932213] ; National Natural Science Foundation of China[22122502] ; National Natural Science Foundation of China[51972090] ; National Natural Science Foundation of China[51702309] ; National Natural Science Foundation of China[81801831] ; National Key Research and Development Program of China[2021YFA0715700] ; National Key Research and Development Program of China[2018YFE0202201] ; Fundamental Research Funds for the Central Universities[WK9110000062] ; Fundamental Research Funds for the Central Universities[WK2060190056] ; University Synergy Innovation Program of Anhui Province[GXXT-2019-028] ; Science and Technology Major Project of Anhui Province[201903a05020003] ; Natural Science Foundation of Anhui Province[2008085J06] ; Natural Science Foundation of Anhui Province[1708085ME114] ; China Postdoctoral Science Foundation[2015M570540] ; Major/Innovative Programof Development Foundation of Hefei Center for Physical Science and Technology[2016FXZY005] ; German Research Foundation, DFG
WOS关键词	HUMAN SERUM ; GADOLINIUM ; NANOPARTICLES ; TRANSMETALATION ; TRANSFORMATION ; STABILITY ; MAGNESIUM ; PHASE
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	NATURE PORTFOLIO
WOS记录号	WOS:000847533800013
资助机构	National Natural Science Foundation of China ; National Key Research and Development Program of China ; Fundamental Research Funds for the Central Universities ; University Synergy Innovation Program of Anhui Province ; Science and Technology Major Project of Anhui Province ; Natural Science Foundation of Anhui Province ; China Postdoctoral Science Foundation ; Major/Innovative Programof Development Foundation of Hefei Center for Physical Science and Technology ; German Research Foundation, DFG
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/128828]
专题	中国科学院合肥物质科学研究院
通讯作者	Lu, Yang; Colfen, Helmut; Yu, Shu-Hong
作者单位	1.Univ Sci & Technol China, Anhui Engn Lab Biomimet Mat, Inst Biomimet Mat & Chem,Inst Energy,Hefei Compre, Div Nanomat & Chem,Dept Chem,Hefei Natl Res Ctr P, Hefei 230026, Peoples R China 2.Chinese Acad Sci, Univ Chinese Acad Sci, Inst Basic Med & Canc IBMC, Canc Hosp,Zhejiang Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China 3.Hefei Univ Technol, Sch Chem & Chem Engn, Anhui Prov Key Lab Adv Catalyt Mat & React Engn, Hefei 230009, Peoples R China 4.Univ Sci & Technol China, Anhui Prov Hosp, Dept Radiol, Affiliated Hosp 1, Hefei 230001, Peoples R China 5.Leibniz Univ Hannover, Inst Inorgan Chem, Callinstr 9, D-30167 Hannover, Germany 6.Univ Konstanz, Dept Chem, Phys Chem, Univ Str 10, D-78457 Constance, Germany 7.Empa, Ctr Xray Analyt, Swiss Fed Labs Mat Sci & Technol, Lerchenfeldstr 5, CH-9014 St Gallen, Switzerland 8.Anhui Med Univ, Dept Blood Transfus, Affiliated Hosp 1, Hefei 230022, Peoples R China
推荐引用方式 GB/T 7714	Dong, Liang,Xu, Yun-Jun,Sui, Cong,et al. Highly hydrated paramagnetic amorphous calcium carbonate nanoclusters as an MRI contrast agent[J]. NATURE COMMUNICATIONS,2022,13.
APA	Dong, Liang.,Xu, Yun-Jun.,Sui, Cong.,Zhao, Yang.,Mao, Li-Bo.,...&Yu, Shu-Hong.(2022).Highly hydrated paramagnetic amorphous calcium carbonate nanoclusters as an MRI contrast agent.NATURE COMMUNICATIONS,13.
MLA	Dong, Liang,et al."Highly hydrated paramagnetic amorphous calcium carbonate nanoclusters as an MRI contrast agent".NATURE COMMUNICATIONS 13(2022).