Hepatoprotective Effect of Oyster Peptide on Alcohol-Induced Liver Disease in Mice

doi:10.3390/ijms23158081

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	Hepatoprotective Effect of Oyster Peptide on Alcohol-Induced Liver Disease in Mice
	Wang, Xueqin 1,2,3; Yu, Huahua 1,2,3; Xing, Ronge 1,2,3; Li, Pengcheng 1,2,3
刊名	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
	2022-08-01
卷号	23 期号:15 页码:15
关键词	oyster peptide alcohol-induced liver diseases hepatoprotective effect oxidative stress inflammatory response
DOI	10.3390/ijms23158081
通讯作者	Li, Pengcheng(pcli@qdio.ac.cn)
英文摘要	Alcohol-induced liver disease (ALD) has become one of the major global health problems, and the aim of this study was to investigate the characterization of the structure as well as the hepatoprotective effect and mechanism of oyster peptide (OP, MW < 3500 Da) on ALD in a mouse model. The results demonstrate that ethanol administration could increase the activities of aspartate aminotransferase (AST), alanine transaminase (ALT), gamma-Glutamyl transferase (GGT), reactive oxygen species (ROS), malondialdehyde (MDA), and triglycerides (TG), as well as increase the interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), and tumor necrosis factor (TNF-alpha) levels (p < 0.01), and reduce the activity of superoxide dismutase (SOD) and the concentration of glutathione (GSH). Those changes were significantly reversed by the application of different doses of OP. Furthermore, the mRNA expressions of nuclear factor elythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), and quinone oxidoreductase1 (NQO1) were significantly up-regulated in OP groups, and the mRNA expressions of nuclear factor kappa-light chain enhancer of B cells (NF-kappa B), TNF-alpha, and IL-6 were markedly reduced in OP groups compared to that of the model group. Thus, OP had a significant protective effect on ALD through the enhancement of the in vivo antioxidant ability and the inhibition of the inflammatory response as possible mechanisms of action, which therefore suggests that OP might be useful as a natural source to protect the liver from alcohol damage.
资助项目	Key Projects for Major Projects on the Transformation of Old and Novel Kinetic Energy of Shandong Province[2020-1220] ; STS Project of the Chinese Academy of Sciences[2021T3038]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	MDPI
WOS记录号	WOS:000839141400001
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/179898]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Li, Pengcheng
作者单位	1.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Megasci, Inst Oceanol, Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Megasci, Inst Oceanol, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Wang, Xueqin,Yu, Huahua,Xing, Ronge,et al. Hepatoprotective Effect of Oyster Peptide on Alcohol-Induced Liver Disease in Mice[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2022,23(15):15.
APA	Wang, Xueqin,Yu, Huahua,Xing, Ronge,&Li, Pengcheng.(2022).Hepatoprotective Effect of Oyster Peptide on Alcohol-Induced Liver Disease in Mice.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,23(15),15.
MLA	Wang, Xueqin,et al."Hepatoprotective Effect of Oyster Peptide on Alcohol-Induced Liver Disease in Mice".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23.15(2022):15.