A c-MET-Targeted Topical Fluorescent Probe cMBP-ICG Improves Oral Squamous Cell Carcinoma Detection in Humans

doi:10.1245/s10434-022-12532-x

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	A c-MET-Targeted Topical Fluorescent Probe cMBP-ICG Improves Oral Squamous Cell Carcinoma Detection in Humans
	Wang, Jingbo 3; Li, Siyi 4; Wang, Kun 1; Zhu, Ling 3; Yang, Lin 3; Zhu, Yunjing 3; Zhang, Zhen 4; Hu, Longwei 4; Yuan, Yuan 3; Fan, Qi 3
刊名	ANNALS OF SURGICAL ONCOLOGY
	2022-10-02
页码	11
ISSN号	1068-9265
DOI	10.1245/s10434-022-12532-x
通讯作者	Yuan, Ying(yuany83@163.com) ; Huang, Ruimin(rmhuang@simm.ac.cn) ; Tian, Jie(tian@ieee.org) ; Tao, Xiaofeng(cjr.taoxiaofeng@vip.163.com)
英文摘要	Introduction The postoperative survival of oral squamous cell carcinoma (SCC) relies on precise detection and complete resection of original tumors. The mucosal extension of the tumor is evaluated visually during surgery, but small and flat foci are difficult to detect. Real-time fluorescence imaging may improve detection of tumor margins. Materials and Methods In the current study, a peptide-based near-infrared (NIR) fluorescence dye, c-MET-binding peptide-indocyanine green (cMBP-ICG), which specifically targets tumor via c-MET binding, was synthetized. A prospective pilot clinical trial then was conducted with oral SCC patients and intraoperatively to assess the feasibility of cMBP-ICG used to detect tumors margins. Fluorescence was histologically correlated to determine sensitivity and specificity. Results The immunohistochemistry (IHC) results demonstrated increased c-Met expression in oral SCC compared with normal mucosa. Tumor-to-background ratios ranged from 2.71 +/- 0.7 to 3.11 +/- 1.2 in different concentration groups. From 10 patients with oral SCC, 60 specimens were collected from tumor margins. The sensitivity and specificity of discriminative value derived from cMBP-ICG application in humans were respectively 100% and 75%. Conclusions Topical application of cMBP-ICG is feasible and safe for optimizing intraoperative visualization and tumor margin detection in oral SCC patients, which could clinically increase the probability of complete resections and improve oncologic outcomes.
资助项目	National Natural Science Foundation of China[91859202] ; National Natural Science Foundation of China[82172049] ; National Natural Science Foundation of China[91859106] ; National Natural Science Foundation of China[82172001]
WOS关键词	HEAD ; CANCER ; NANOPARTICLES ; OROPHARYNGEAL ; PROGRESSION ; EXPRESSION
WOS研究方向	Oncology ; Surgery
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000863965500002
资助机构	National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/50373]
专题	自动化研究所_中国科学院分子影像重点实验室
通讯作者	Yuan, Ying; Huang, Ruimin; Tian, Jie; Tao, Xiaofeng
作者单位	1.Chinese Acad Sci, Beijing Key Lab Mol Imaging, Inst Automat,State Key Lab Management & Control, CAS Key Lab Mol Imaging, Beijing, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, Shanghai, Peoples R China 3.Shanghai Jiao Tong Univ, Sch Med, Peoples Hosp 9, Dept Radiol, Shanghai, Peoples R China 4.Shanghai Jiao Tong Univ, Sch Med, Peoples Hosp 9, Dept Oral & Maxillofacial Head & Neck Oncol, Shanghai, Peoples R China 5.Shanghai Jiao Tong Univ, Sch Med, Peoples Hosp 9, Dept Pathol, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Wang, Jingbo,Li, Siyi,Wang, Kun,et al. A c-MET-Targeted Topical Fluorescent Probe cMBP-ICG Improves Oral Squamous Cell Carcinoma Detection in Humans[J]. ANNALS OF SURGICAL ONCOLOGY,2022:11.
APA	Wang, Jingbo.,Li, Siyi.,Wang, Kun.,Zhu, Ling.,Yang, Lin.,...&Tao, Xiaofeng.(2022).A c-MET-Targeted Topical Fluorescent Probe cMBP-ICG Improves Oral Squamous Cell Carcinoma Detection in Humans.ANNALS OF SURGICAL ONCOLOGY,11.
MLA	Wang, Jingbo,et al."A c-MET-Targeted Topical Fluorescent Probe cMBP-ICG Improves Oral Squamous Cell Carcinoma Detection in Humans".ANNALS OF SURGICAL ONCOLOGY (2022):11.