Colourful fluorescence-based carbon dots for tumour imaging-guided nanosurgery

doi:10.1016/j.nano.2022.102583

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	Colourful fluorescence-based carbon dots for tumour imaging-guided nanosurgery
	Shang, Wenting 2; Xia, Xueer 1; Lu, Ningning 2; Gao, Pengli 3; Peng, Li 2; Liu, Yu 3; Deng, Han 2; Jiang, Jingying 3,6; Li, Zhou 1,7; Liu, Jianhua 4,5
刊名	NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
	2022-09-01
卷号	45 页码:11
关键词	Carbon dots Fluorescent probe Multicolour cancer therapy Nano-theranostic
ISSN号	1549-9634
DOI	10.1016/j.nano.2022.102583
通讯作者	Jiang, Jingying(jingyingjiang@buaa.edu.cn) ; Li, Zhou(gzlizhou@smu.edu.cn) ; Liu, Jianhua(liujianh80@126.com)
英文摘要	Fluorescent-intraoperative navigation is a visual technique that allows surgeons to accurately distinguish malignant and normal tissues during surgery. It has the advantages of immediacy, high resolution, and high specificity. However, a single fluorescent source cannot provide sufficient surgical information. Multicolour carbon dots (CDs) are more suitable since they provide outstanding water solubility, photo -stability, and multicolour-fluorescence imaging. Here, we prepared an optical probe with CD-based multicolour-fluorescence imaging via a hydrothermal method. CDs can be endocytosed by tumour cells, and after intravenous injection, they can effectively accumulate at the tumour site. In a pancreatic cancer mouse model, we demonstrated the multicolour-fluorescence imaging capabilities of CDs, which aided the accurate resection of tumours under fluorescent-intraoperative navigation. Stereoscopic fluorescence microscopy imaging and H&E staining proved that the removed tissue belonged to the pancreatic tumour. This study emphasizes the potential of CDs for fluorescence-guided intraoperative resection and expands the application of CDs in biological fields.(c) 2022 Published by Elsevier Inc.
资助项目	National Natural Science Foundation of China[81971680] ; National Natural Science Foundation of China[81971662] ; National Natural Science Foundation of China[62027901] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81930053] ; Natural Science Foundation of Beijing City[7202105] ; Research Start-up Funds for National Natural Science Foundation of China[8200110771] ; Research Start-up Funds for National Natural Science Foundation of China[8190110562]
WOS关键词	ACID
WOS研究方向	Science & Technology - Other Topics ; Research & Experimental Medicine
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000853225100001
资助机构	National Natural Science Foundation of China ; Natural Science Foundation of Beijing City ; Research Start-up Funds for National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/50086]
专题	自动化研究所_中国科学院分子影像重点实验室
通讯作者	Jiang, Jingying; Li, Zhou; Liu, Jianhua
作者单位	1.Southern Med Univ, Zhujiang Hosp, Gen Surg Ctr, Dept Gastrointestinal Surg, Guangzhou 510000, Peoples R China 2.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing Key Lab Mol Imaging,State Key Lab Managem, Beijing 100190, Peoples R China 3.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med & Engn, Beijing 100191, Peoples R China 4.Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Canc Ctr, Dept Oncol, Guangzhou 510000, Peoples R China 5.Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Dept Oncol, 123 Huifu Rd West, Guangzhou 510180, Peoples R China 6.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med & Engn, Beijing, Peoples R China 7.Southern Med Univ, Zhujiang Hosp, Gen Surg Ctr, Dept Gastrointestinal Surg, 253 Gongye Middle Ave, Guangzhou 510280, Peoples R China
推荐引用方式 GB/T 7714	Shang, Wenting,Xia, Xueer,Lu, Ningning,et al. Colourful fluorescence-based carbon dots for tumour imaging-guided nanosurgery[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2022,45:11.
APA	Shang, Wenting.,Xia, Xueer.,Lu, Ningning.,Gao, Pengli.,Peng, Li.,...&Liu, Jianhua.(2022).Colourful fluorescence-based carbon dots for tumour imaging-guided nanosurgery.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,45,11.
MLA	Shang, Wenting,et al."Colourful fluorescence-based carbon dots for tumour imaging-guided nanosurgery".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 45(2022):11.