Preparation, Optimization and Characterization of Podophyllotoxin Loaded Chitosan Microparticles by Ionic Cross-Linking Method

	Preparation, Optimization and Characterization of Podophyllotoxin Loaded Chitosan Microparticles by Ionic Cross-Linking Method
	Xu, XL; Li, CX; Liu, YY; Duo, J; Song, WZ; Feng, HS; Ma, Z
刊名	LATIN AMERICAN JOURNAL OF PHARMACY
	2021
卷号	40 期号:12 页码:3031
英文摘要	In order to improve the short metabolic time and low bioavailability of podophyllotoxin (PPT) in the body, podophyllotoxin loaded chitosan microparticles (PPT-CS-MPs) were prepared by ionic cross-linking method. The preparation conditions optimized by single factor experiment and response surface methodology were as follows: 2 mg/mL of chitosan, 1 mg/mL of TPP, acetic acid pH 3-4, 3 min of homogenizing time, 7 Kr/min of homogenizing rate, 40 min of magnetic stirring time. The PPT loading capacity of the PPT-CS-MPs was observed as 31 mg/g, and the encapsulation efficiency was up to 50.32%. The morphologies of the system were observed by scanning electron microscopy (SEM), and it showed the spherical microparticles with d(0.5) 58.14 mu m. The FTIR results showed that there was a weak physical interaction between PPT and chitosan. The DSC analysis indicated the formation of non-crystallinic PPT in microparticles. The in vitro release studies demonstrated longer release properties of PPT-CS-MPs. Cell cytotoxicity results showed the better cytotoxicity of PPT-CS-MPs. This work suggested that the prepared PPT-CS-MPs could realize slow release characteristics and improve the utilization, which exhibit good potential for the new formulation development of PPT.
内容类型	期刊论文
源URL	[http://210.75.249.4/handle/363003/61381]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Xu, XL,Li, CX,Liu, YY,et al. Preparation, Optimization and Characterization of Podophyllotoxin Loaded Chitosan Microparticles by Ionic Cross-Linking Method[J]. LATIN AMERICAN JOURNAL OF PHARMACY,2021,40(12):3031.
APA	Xu, XL.,Li, CX.,Liu, YY.,Duo, J.,Song, WZ.,...&Ma, Z.(2021).Preparation, Optimization and Characterization of Podophyllotoxin Loaded Chitosan Microparticles by Ionic Cross-Linking Method.LATIN AMERICAN JOURNAL OF PHARMACY,40(12),3031.
MLA	Xu, XL,et al."Preparation, Optimization and Characterization of Podophyllotoxin Loaded Chitosan Microparticles by Ionic Cross-Linking Method".LATIN AMERICAN JOURNAL OF PHARMACY 40.12(2021):3031.