Screening for alpha-Glucosidase-Inhibiting Saponins from Pressurized Hot Water Extracts of Quinoa Husks

	Screening for alpha-Glucosidase-Inhibiting Saponins from Pressurized Hot Water Extracts of Quinoa Husks
	Su, R; Li, J; Hu, N; Wang, HL; Cao, JY; Chi, XF; Dong, Q
刊名	FOODS
	2022
卷号	11 期号:19
英文摘要	The present study extracted total saponins from quinoa husks with pressurized hot water extraction and optimized the extraction conditions. The response surface methodology (RSM) with a Box-Behnken design (BBD) was employed to investigate the effects of extraction flow rate, extraction temperature and extraction time on the extraction yield of total saponins. A maximal yield of 23.06 mg/g was obtained at conditions of 2 mL/min, 210 degrees C and 50 min. The constituents of the extracts were analyzed by liquid chromatography-mass spectrometry (LC-MS). A total of twenty-three compounds were identified, including five flavonoids, seventeen triterpenoid saponins and a phenolic acid. Moreover, we performed an in vitro assay for the alpha-glucosidase activity and found a stronger inhibitory effect of the quinoa husk extracts than acarbose, suggesting its potential to be developed into functional products with hypoglycemic effect. Finally, our molecular docking analyses indicated triterpenoid saponins as the main bioactive components.
内容类型	期刊论文
源URL	[http://210.75.249.4/handle/363003/61096]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Su, R,Li, J,Hu, N,et al. Screening for alpha-Glucosidase-Inhibiting Saponins from Pressurized Hot Water Extracts of Quinoa Husks[J]. FOODS,2022,11(19).
APA	Su, R.,Li, J.,Hu, N.,Wang, HL.,Cao, JY.,...&Dong, Q.(2022).Screening for alpha-Glucosidase-Inhibiting Saponins from Pressurized Hot Water Extracts of Quinoa Husks.FOODS,11(19).
MLA	Su, R,et al."Screening for alpha-Glucosidase-Inhibiting Saponins from Pressurized Hot Water Extracts of Quinoa Husks".FOODS 11.19(2022).