Preparation and antioxidant activity of novel chitosan oligosaccharide quinolinyl urea derivatives

doi:10.1016/j.carres.2022.108678

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 海岸带生物学与生物资源利用重点实验室

	Preparation and antioxidant activity of novel chitosan oligosaccharide quinolinyl urea derivatives
	Wang, Linqing 3; Liu, Xiguang 3; Tan, Wenqiang 2; Li, Qing 2; Guo, Zhanyong 1,2; Zhang, Jingjing 2
刊名	CARBOHYDRATE RESEARCH
	2022-11-01
卷号	521 页码:8
关键词	Chitosan Oligosaccharide Quinolinyl urea derivatives Antioxidant activity Cytotoxicity
ISSN号	0008-6215
DOI	10.1016/j.carres.2022.108678
通讯作者	Liu, Xiguang(xgliu1986@163.com) ; Zhang, Jingjing(jingjingzhang@yic.ac.cn)
英文摘要	In the present study, four new chitosan oligosaccharide derivatives bearing quinolinyl urea groups were syn-thesized by reaction between 2-methoxyformylated chitosan oligosaccharide and aminoquinoline. The chitosan oligosaccharide derivatives were characterized by Fourier Transform Infrared (FTIR) and 1H Nuclear Magnetic Resonance (1H NMR) spectroscopy. The obtained results confirmed that chitosan oligosaccharide quinolinyl urea derivatives were successfully synthesized. Meanwhile, the antioxidant activities of different chitosan oligosac-charide derivatives were examined in vitro. Experimentally, it was demonstrated that chitosan oligosaccharide quinolinyl urea derivatives had superior antioxidant activity compared with chitosan oligosaccharide and the antioxidant effects were concentration-dependent. Especially, when the concentration was 1.6 mg/mL, their superoxide anion radical scavenging rates could reach to 72.35 +/- 0.49%, 100.00 +/- 0.21%, 84.63 +/- 0.49%, and 87.22 +/- 0.32%, respectively. And the hydroxyl radical scavenging rates could reach to 100.00 +/- 0.82%, 98.49 +/- 4.08%, 100.00 +/- 5.76%, and 92.07 +/- 5.10%. In addition, the cytotoxic activity of the prepared chitosan derivatives against L929 cells was determined by CCK-8 assay. The cell survival rates were all higher than 90%, which intuitively indicated that the samples had almost no cytotoxicity. The findings indicated that the enhanced antioxidant property and biocompatibility of these chitosan oligosaccharide quinolinyl urea derivatives could enlarge the scope of the application of chitosan oligosaccharide, particularly as an antioxidant in food packaging, biomedical, pharmaceutical, cosmetics industries and other fields.
WOS关键词	ANTIBACTERIAL ; ANTIFUNGAL ; DNA
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
WOS记录号	WOS:000862503600004
资助机构	National Key Research and Development Program of China ; Natural Science Foundation of Shandong Province of China ; Youth Innovation Promotion Association CAS ; Chinese Academy of Sciences
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/31739]
专题	海岸带生物学与生物资源利用重点实验室
通讯作者	Liu, Xiguang; Zhang, Jingjing
作者单位	1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China 3.Ludong Univ, Sch Chem & Mat Sci, Yantai 264025, Peoples R China
推荐引用方式 GB/T 7714	Wang, Linqing,Liu, Xiguang,Tan, Wenqiang,et al. Preparation and antioxidant activity of novel chitosan oligosaccharide quinolinyl urea derivatives[J]. CARBOHYDRATE RESEARCH,2022,521:8.
APA	Wang, Linqing,Liu, Xiguang,Tan, Wenqiang,Li, Qing,Guo, Zhanyong,&Zhang, Jingjing.(2022).Preparation and antioxidant activity of novel chitosan oligosaccharide quinolinyl urea derivatives.CARBOHYDRATE RESEARCH,521,8.
MLA	Wang, Linqing,et al."Preparation and antioxidant activity of novel chitosan oligosaccharide quinolinyl urea derivatives".CARBOHYDRATE RESEARCH 521(2022):8.