A Raman/fluorescence dual-modal imaging guided synergistic photothermal and photodynamic therapy nanoplatform for precision cancer theranostics

doi:10.1039/d2tb01696f

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 中科院海岸带环境过程与生态修复重点实验室

	A Raman/fluorescence dual-modal imaging guided synergistic photothermal and photodynamic therapy nanoplatform for precision cancer theranostics
	Fu, Lili 2,3; Huang, Yan 2,3; Hou, Junjun 2,3; Sun, Mingzhao 2,3; Wang, Lingxiao 2,3; Wang, Xiaoyan 2,3; Chen, Lingxin 1,2,3
刊名	JOURNAL OF MATERIALS CHEMISTRY B
	2022-09-15
页码	11
ISSN号	2050-750X
DOI	10.1039/d2tb01696f
通讯作者	Huang, Yan(yhuang@yic.ac.cn) ; Wang, Xiaoyan(wangxy@yic.ac.cn) ; Chen, Lingxin(lxchen@yic.ac.cn)
英文摘要	Nanoparticle-based phototherapies, such as photodynamic therapy (PDT) and photothermal therapy (PTT) are effective methods for tumor theranostics. However, there are still some problems such as lack of specificity to the special internal environment and difficulty in tumor localization. In this study, we design a near-infrared (NIR) fluorescent guided tumor therapy nanoplatform Cy-C-S-NPs for tumor therapy and precise localization. First, we synthesized a near-infrared fluorescent dye Cy-DM, combined with excellent optical and PDT/PTT properties. Interestingly, it binds Cy7 to the azo bond and mercaptoacetic acid and in the meanwhile the azo bond can be broken specifically under the condition of tumor hypoxia. Then the Au-S bond is covalently coupled with C-S-NPs, a gold nanomaterial similar to waxberry with surface-enhanced Raman function, to form the Cy-C-S-NP nanomaterial and achieve Raman imaging. In a non-anoxic environment, Cy-DM fluorescence is quenched by C-S-NPs. The unique hypoxic microenvironment of tumor cells leads to the breaking of azo bonds, releasing Cy-DM and producing fluorescence. Accurate tumor localization based on near infrared imaging diagnosis and dependent on the release of Cy-DM and C-S-NPs, PDT/PTT therapy can be performed effectively. This study provides an interesting nanoplatform that combines the functions of PDT/PTT with dual imaging effects of fluorescence and Raman imaging. This multifunctional nanoplatform may be a promising nanoplatform for targeted tumor imaging and precision therapy.
WOS关键词	PHOTOTHERMAL/PHOTODYNAMIC THERAPY ; TUMOR MICROENVIRONMENT ; NANOPARTICLES ; CELLS ; NANOCLUSTERS ; NANOCARRIERS ; COMBINATION ; PROTEINS ; POLYMERS ; RELEASE
WOS研究方向	Materials Science
语种	英语
WOS记录号	WOS:000862881400001
资助机构	National Natural Science Foundation of China ; Science and Technology Innovation Development Plan of Yantai of China ; Research Initiation Fund of Binzhou Medical University ; Taishan Scholar Project Special Funding ; Shandong Peninsula Engineering Research Center of Comprehensive Brine Utilization
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/31715]
专题	烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
通讯作者	Huang, Yan; Wang, Xiaoyan; Chen, Lingxin
作者单位	1.Qingdao Univ Technol, Sch Environm & Municipal Engn, Qingdao 266033, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China 3.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Fu, Lili,Huang, Yan,Hou, Junjun,et al. A Raman/fluorescence dual-modal imaging guided synergistic photothermal and photodynamic therapy nanoplatform for precision cancer theranostics[J]. JOURNAL OF MATERIALS CHEMISTRY B,2022:11.
APA	Fu, Lili.,Huang, Yan.,Hou, Junjun.,Sun, Mingzhao.,Wang, Lingxiao.,...&Chen, Lingxin.(2022).A Raman/fluorescence dual-modal imaging guided synergistic photothermal and photodynamic therapy nanoplatform for precision cancer theranostics.JOURNAL OF MATERIALS CHEMISTRY B,11.
MLA	Fu, Lili,et al."A Raman/fluorescence dual-modal imaging guided synergistic photothermal and photodynamic therapy nanoplatform for precision cancer theranostics".JOURNAL OF MATERIALS CHEMISTRY B (2022):11.