Interplay of receptor-ligand binding and lipid domain formation during cell adhesion

doi:10.3389/fmolb.2022.1019477

CORC > 力学研究所 > 中国科学院力学研究所 > 非线性力学国家重点实验室

	Interplay of receptor-ligand binding and lipid domain formation during cell adhesion
	Li L(李龙); Hu, Jinglei 7; Rozycki, Bartosz 4; Ji, Jing 3; Song F(宋凡)
刊名	FRONTIERS IN MOLECULAR BIOSCIENCES
	2022-09
卷号	9 页码:1019477
关键词	cell adhesion receptor-tigand binding lipid domain formation binding affinity binding cooperativity phase separation
DOI	10.3389/fmolb.2022.1019477
英文摘要	Cell adhesion involved in biological processes such as cell migration, immune responses, and cancer metastasis, is mediated by the specific binding of receptor and ligand proteins. Some of these proteins exhibit affinity for nanoscale lipid clusters in cell membranes. A key question is how these nanoscale lipid clusters influence and react to the receptor-ligand binding during cell adhesion. In this article, we review recent computational studies that shed new light on the interplay of the receptor-ligand binding and the formation of lipid domains in adhering membranes. These studies indicate that the receptor- ligand binding promotes coalescence of lipid clusters into mesoscale domains, which, in turn, enhances both the affinity and cooperativity of the receptor-ligand binding in cell-cell adhesion with mobile ligands. In contrast, in the case of cell-extracellular matrix adhesion with immobile ligands, the receptor- ligand binding and the lipid cluster coalescence can be correlated or anti-correlated, depending strongly on the ligand distribution. These findings deepen our understanding of correlations between cell adhesion and membrane heterogeneities.
学科主题	Biochemistry & Molecular Biology
分类号	二类/Q1
语种	英语
WOS记录号	WOS:000864008900001
资助机构	National Natural Science Foundation of China [11902327, 1197204, 21973040, 12272388, 12232019, 22161132012] ; Youth In11ation Promotion Association CAS ; National Science Centre of Poland [2021/40/Q/NZ1/00017]
其他责任者	Hu, JL (corresponding author), Nanjing Univ, Kuang Yaming Honors Sch, Nanjing, Peoples R China. ; Hu, JL (corresponding author), Nanjing Univ, Inst Brain Sci, Nanjing, Peoples R China. ; Rozycki, B (corresponding author), Polish Acad Sci, Inst Phys, Warsaw, Poland. ; Ji, J (corresponding author), Beihang Univ, Key Lab Biomech & Mechanobiol, Minist Educ, Beijing Adv In11at Ctr Biomed Engn,Sch Biol Sci, Beijing, Peoples R China.
内容类型	期刊论文
源URL	[http://dspace.imech.ac.cn/handle/311007/90168]
专题	力学研究所_非线性力学国家重点实验室
作者单位	1.Univ Chinese Acad Sci, Sch Engn Sci, Beijing, Peoples R China 2.Beihang Univ, Key Lab Biomech & Mechanobiol, Minist Educ, Beijing Adv In11at Ctr Biomed Engn,Sch Biol Sci, Beijing, Peoples R China 3.Polish Acad Sci, Inst Phys, Warsaw, Poland 4.Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, Beijing, Peoples R China 5.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing, Peoples R China 6.Nanjing Univ, Inst Brain Sci, Nanjing, Peoples R China 7.Nanjing Univ, Kuang Yaming Honors Sch, Nanjing, Peoples R China
推荐引用方式 GB/T 7714	Li L,Hu, Jinglei,Rozycki, Bartosz,et al. Interplay of receptor-ligand binding and lipid domain formation during cell adhesion[J]. FRONTIERS IN MOLECULAR BIOSCIENCES,2022,9:1019477.
APA	李龙,Hu, Jinglei,Rozycki, Bartosz,Ji, Jing,&宋凡.(2022).Interplay of receptor-ligand binding and lipid domain formation during cell adhesion.FRONTIERS IN MOLECULAR BIOSCIENCES,9,1019477.
MLA	李龙,et al."Interplay of receptor-ligand binding and lipid domain formation during cell adhesion".FRONTIERS IN MOLECULAR BIOSCIENCES 9(2022):1019477.