Skimmianine, a furoquinoline alkaloid from Zanthoxylum nitidum as a potential acetylcholinesterase inhibitor

doi:10.1007/s00044-011-9581-9

	Skimmianine, a furoquinoline alkaloid from Zanthoxylum nitidum as a potential acetylcholinesterase inhibitor
	Yang, Zhong-duo; Zhang, Dong-bo; Ren, Jin; Yang, Ming-jun
刊名	MEDICINAL CHEMISTRY RESEARCH
	2012-06
卷号	21 期号:6 页码:722-725
关键词	Zanthoxylum nitidum Skimmianine Acetylcholinesterase inhibitor Quinoline alkaloid Alzheimer's disease
ISSN号	1054-2523
DOI	10.1007/s00044-011-9581-9
英文摘要	Skimmianine (1), a newly discovered strong acetylcholinesterase (AChE) inhibitor, along with nine weakly or no active compounds, toddalolactone (2), dictamnine (3), gamma-fagarine (4), magnolone (5), (-)-(S)-edulinine (6), zanthodioline (7), edulitine (8), 5,6,7-trimethoxycoumarin (9), and haplopine (10) have been isolated from Zanthoxylum nitidum (Z. nitidum). Skimmianine (1) inhibited 50% of AChE activity at the concentrations of 8.6 +/- A 0.7 mu g/ml when the IC50 value of Physostigmine as a standard was 0.013 +/- A 0.002 mu g/ml. Antiacetylcholinesterase activity of skimmianine (1) was also supported by TLC bioautographic assay. The structure activity relationship on the anti-acetylcholinesterase activity of the quinoline moiety is also discussed in this article.
资助项目	National Natural Science Foundation of China[20802031] ; Lanzhou University of Technology[Q200904]
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	SPRINGER BIRKHAUSER
WOS记录号	WOS:000303471900005
状态	已发表
内容类型	期刊论文
源URL	[http://119.78.100.223/handle/2XXMBERH/34898]
专题	生命科学与工程学院
通讯作者	Yang, Zhong-duo
作者单位	Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730050, Peoples R China
推荐引用方式 GB/T 7714	Yang, Zhong-duo,Zhang, Dong-bo,Ren, Jin,et al. Skimmianine, a furoquinoline alkaloid from Zanthoxylum nitidum as a potential acetylcholinesterase inhibitor[J]. MEDICINAL CHEMISTRY RESEARCH,2012,21(6):722-725.
APA	Yang, Zhong-duo,Zhang, Dong-bo,Ren, Jin,&Yang, Ming-jun.(2012).Skimmianine, a furoquinoline alkaloid from Zanthoxylum nitidum as a potential acetylcholinesterase inhibitor.MEDICINAL CHEMISTRY RESEARCH,21(6),722-725.
MLA	Yang, Zhong-duo,et al."Skimmianine, a furoquinoline alkaloid from Zanthoxylum nitidum as a potential acetylcholinesterase inhibitor".MEDICINAL CHEMISTRY RESEARCH 21.6(2012):722-725.