A Novel Molecularly Imprinted Electrochemical Sensor Based on PANI@GO for Highly Sensitive and Selective Analysis of Trace Epigoitrin

doi:10.1149/1945-7111/ac8508

	A Novel Molecularly Imprinted Electrochemical Sensor Based on PANI@GO for Highly Sensitive and Selective Analysis of Trace Epigoitrin
	Sun, Bolu 2; Gao, Chengyang 2; Yang, Lin 2; Shi, Hongxia 3; Kan, Lei 2; Ma, Quhuan 1; Shi, Xiaofeng 1
刊名	JOURNAL OF THE ELECTROCHEMICAL SOCIETY
	2022-08-01
卷号	169 期号:8
ISSN号	0013-4651
DOI	10.1149/1945-7111/ac8508
英文摘要	Identification and quantification of epigoitrin (EP) in some herbs and traditional Chinese medicine (TCM) preparations are critical to pharmacokinetic study and pharmaceutical quality control due to its distinct antiviral activity. So, developing highly sensitive and selective method for detection of EP is essential for clinical treatment and drug development. In this study, a novel molecularly imprinted electrochemical sensor for detection of EP was firstly constructed. With acrylamide imprinting systems, surface imprinting on the polyaniline functionalized graphene oxide was employed to prepare molecularly imprinted polymer by electro-polymerization, which follow-up constructed afford specific binding cavities, endowing the exclusive recognition ability. Furthermore, the polyacrylamide chain is anchored to the polyaniline chain by covalent bonds, which is beneficial for raising electrochemistry signal. Under the optimized condition, the sensor demonstrates a linear wide range of 4.6 x 10(-7) mol l(-1) similar to 4.6 x 10(-5) mol l(-1) with a correlation coefficient of 0.9953 and a low LOD of 8.21 x 10(-8) mol l(-1) (S/N = 3). Additionally, the sensor showed good stability, repeatability (RSD 1.52%) and selectivity. The method was applied to analyze EP in the extraction from Isatidis Radix with a recovery higher than 97.8% and RSD less than 1.81%. This work provided a novel strategy for on-site, realtime and rapid detection of indicator components from TCM. (C) 2022 The Electrochemical Society (ECS). Published on behalf of ECS by IOP Publishing Limited.
WOS研究方向	Electrochemistry ; Materials Science
语种	英语
出版者	ELECTROCHEMICAL SOC INC
WOS记录号	WOS:000835780500001
内容类型	期刊论文
源URL	[http://ir.lut.edu.cn/handle/2XXMBERH/159828]
专题	生命科学与工程学院
作者单位	1.Gansu Acad Med Sci, Lanzhou 730050, Peoples R China 2.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730000, Gansu, Peoples R China; 3.Lanzhou Zhongjianke Testing Technol Co Ltd, Lanzhou 730000, Gansu, Peoples R China;
推荐引用方式 GB/T 7714	Sun, Bolu,Gao, Chengyang,Yang, Lin,et al. A Novel Molecularly Imprinted Electrochemical Sensor Based on PANI@GO for Highly Sensitive and Selective Analysis of Trace Epigoitrin[J]. JOURNAL OF THE ELECTROCHEMICAL SOCIETY,2022,169(8).
APA	Sun, Bolu.,Gao, Chengyang.,Yang, Lin.,Shi, Hongxia.,Kan, Lei.,...&Shi, Xiaofeng.(2022).A Novel Molecularly Imprinted Electrochemical Sensor Based on PANI@GO for Highly Sensitive and Selective Analysis of Trace Epigoitrin.JOURNAL OF THE ELECTROCHEMICAL SOCIETY,169(8).
MLA	Sun, Bolu,et al."A Novel Molecularly Imprinted Electrochemical Sensor Based on PANI@GO for Highly Sensitive and Selective Analysis of Trace Epigoitrin".JOURNAL OF THE ELECTROCHEMICAL SOCIETY 169.8(2022).