Preparation of Codonopsis pilosula polysaccharide microcapsules and its effect and mechanism on skin wound healing in rats

doi:10.1177/08853282211054333

	Preparation of Codonopsis pilosula polysaccharide microcapsules and its effect and mechanism on skin wound healing in rats
	Yang, Mingjun 1; Jin, Yongming 1; Yang, Jumei 2; Wang, Chenliang 1; Wang, Xinjian 1; Wang, Yonggang 1
刊名	Journal of Biomaterials Applications
	2022-05-01
卷号	36 期号:10 页码:1723-1736
关键词	Cell culture Genes Particle size Physicochemical properties Polysaccharides Rats RNA Tissue regeneration Characteristic properties Codonopsi pilosulum polysaccharide Extraction process Microcapsules Particles sizes Physicochemical property Rat model Structural characteristics Swelling degree Wound healing
ISSN号	0885-3282
DOI	10.1177/08853282211054333
英文摘要	In this study, after optimizing the extraction process of CPP (Codonopsis pilosula polysaccharides), CPPM (CPP microcapsules) were prepared. Subsequently, the structural characteristics and physicochemical properties were studied. The results showed that CPPM is a hollow sac-like structure with rough folds and protuberances and comes in spherical or ellipsoidal shapes with uniform particle size. CPPM has certain swelling degree, low hardness, good adhesion, and stability. Then, the effect of CPPM on wounds repair was investigated by a rat model. The results showed that CPPM could improve the wound healing rate. Histological evaluation showed CPPM could promote neovascularization and fibroblast proliferation. By investigating the healing mechanism, it was found that CPPM increased the hydroxyproline content in granulation tissue and had an excellent antioxidant ability, and then inhibited lipid peroxidation, in addition, it significantly increased the transcript levels of VEGF and miRNA-21 genes, indicating that CPPM play an influential role in vascular remodeling during wound healing by up-regulating the expression of VEGF and miRNA-21 genes. © The Author(s) 2022.
WOS研究方向	Engineering ; Materials Science
语种	英语
出版者	SAGE Publications Ltd
WOS记录号	WOS:000764247800001
内容类型	期刊论文
源URL	[http://ir.lut.edu.cn/handle/2XXMBERH/157922]
专题	生命科学与工程学院
作者单位	1.School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, China; 2.Lanzhou University Second Hospital, Lanzhou, China
推荐引用方式 GB/T 7714	Yang, Mingjun,Jin, Yongming,Yang, Jumei,et al. Preparation of Codonopsis pilosula polysaccharide microcapsules and its effect and mechanism on skin wound healing in rats[J]. Journal of Biomaterials Applications,2022,36(10):1723-1736.
APA	Yang, Mingjun,Jin, Yongming,Yang, Jumei,Wang, Chenliang,Wang, Xinjian,&Wang, Yonggang.(2022).Preparation of Codonopsis pilosula polysaccharide microcapsules and its effect and mechanism on skin wound healing in rats.Journal of Biomaterials Applications,36(10),1723-1736.
MLA	Yang, Mingjun,et al."Preparation of Codonopsis pilosula polysaccharide microcapsules and its effect and mechanism on skin wound healing in rats".Journal of Biomaterials Applications 36.10(2022):1723-1736.