Stephtetrandrine A-D, bisbenzylisoquinoline alkaloids from Stephania tetrandra

doi:10.1080/14786419.2021.1961135

	Stephtetrandrine A-D, bisbenzylisoquinoline alkaloids from Stephania tetrandra
	Yang, Li-Jun 1,2; Yang, Zhong-Duo 2; Li, Zhi-Jie 2; Yang, Shu-Hong 2; Shu, Zong-Mei 2
刊名	NATURAL PRODUCT RESEARCH
	2021-07
关键词	Stephania tetrandra Menispermaceae structure elucidation bisbenzylisoquinoline alkaloids enzyme inhibition Stephtetrandrine
ISSN号	1478-6419
DOI	10.1080/14786419.2021.1961135
英文摘要	Four undescribed bisbenzylisoquinoline alkaloids, designated as Stephtetrandrine A-D, were isolated from the roots of Stephania tetrandra. Their structures were elucidated by IR, HRESIMS, ECD spectra, 1 D and 2 D NMR spectra and comparison with the literature data. Additional five known compounds (limacine, tetrandrine, N-trans-Feruloyltyramine, 2 '-N-chloromethyltetrandrine, 2,2'-N-N-dichloromethyltetrandrine) were also isolated. N-trans-Feruloyltyramine was isolated from Stephania tetrandra for the first time. The isolated compounds were tested for monoamine oxidase, acetylcholinesterase, phosphoinositide 3-kinase alpha and human hepatoma cell HepG2 inhibitory activities. Stephtetrandrine C showed obvious inhibitory effect on human hepatoma HepG2, with IC50 value of 16.2 mu M. Limacine and 2 '-N-chloromethyltetrandrine showed moderate monoamine oxidase inhibitory effect with the IC50 values of 37.7 and 29.2 mu M, respectively.
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
出版者	TAYLOR & FRANCIS LTD
WOS记录号	WOS:000681509800001
内容类型	期刊论文
源URL	[http://ir.lut.edu.cn/handle/2XXMBERH/148715]
专题	生命科学与工程学院
作者单位	1.Univ Technol, Prov Educ Key Lab Screening Evaluat & Adv Proc Tr, Sch Life Sci & Engn, Lanzhou, Gansu, Peoples R China 2.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou, Gansu, Peoples R China;
推荐引用方式 GB/T 7714	Yang, Li-Jun,Yang, Zhong-Duo,Li, Zhi-Jie,et al. Stephtetrandrine A-D, bisbenzylisoquinoline alkaloids from Stephania tetrandra[J]. NATURAL PRODUCT RESEARCH,2021.
APA	Yang, Li-Jun,Yang, Zhong-Duo,Li, Zhi-Jie,Yang, Shu-Hong,&Shu, Zong-Mei.(2021).Stephtetrandrine A-D, bisbenzylisoquinoline alkaloids from Stephania tetrandra.NATURAL PRODUCT RESEARCH.
MLA	Yang, Li-Jun,et al."Stephtetrandrine A-D, bisbenzylisoquinoline alkaloids from Stephania tetrandra".NATURAL PRODUCT RESEARCH (2021).