Secondary Metabolites and PI3K Inhibitory Activity of Colletotrichum gloeosporioides, a Fungal Endophyte of Uncaria rhynchophylla

doi:10.1007/s00284-019-01707-7

	Secondary Metabolites and PI3K Inhibitory Activity of Colletotrichum gloeosporioides, a Fungal Endophyte of Uncaria rhynchophylla; Secondary Metabolites and PI3K Inhibitory Activity of Colletotrichum gloeosporioides, a Fungal Endophyte of Uncaria rhynchophylla; Secondary Metabolites and PI3K Inhibitory Activity of Colletotrichum gloeosporioides, a Fungal Endophyte of Uncaria rhynchophylla; Secondary Metabolites and PI3K Inhibitory Activity of Colletotrichum gloeosporioides, a Fungal Endophyte of Uncaria rhynchophylla
	Yang ZD(杨中铎)
刊名	Current Microbiology ; Current Microbiology ; Current Microbiology ; Current Microbiology
	2019-07 ; 2019-07 ; 2019-07 ; 2019-07
卷号	76 期号:7 页码:904-908
ISSN号	0343-8651
DOI	10.1007/s00284-019-01707-7
英文摘要	In the present study, nine compounds (1-9) were isolated from Colletotrichum gloeosporioides (an endophytic fungus from Uncaria rhynchophylla) which was cultured in wheat bran medium. Their structures were elucidated as 4-Epi-14-hydroxy-10, 23-dihydro-24, 25-dehydroaflavinine (1), 10, 23-Dihydro-24,25 -dehydro-21-oxoaflavinine (2), Ergosterol (3), Ergosterol peroxide (4), Mellein (5), 4, 5-dihydroblumenol A (6), Colletotrichine A (7), Cyclo(L-leucyl-L-leucyl) (8), and Brevianamide F (9) based on NMR spectral data, as well as comparing with previous literature data. This is the first report about the isolation of compounds 1-2, 6, and 8-9 from Colletotrichum genus. All compounds were tested for their phosphoinositide 3-kinase (PI3K) inhibitory activity. Compounds 8 and 9 showed potent PI3K inhibitory activity with IC50 values of 38.1 and 4.8 mu M, respectively, while the other compounds showed very weak activity at a concentration of 20 mu g/mL.
WOS研究方向	Microbiology
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000469873300016
内容类型	期刊论文
源URL	[http://ir.lut.edu.cn/handle/2XXMBERH/103311]
专题	生命科学与工程学院
通讯作者	Yang ZD(杨中铎)
推荐引用方式 GB/T 7714	Yang ZD. Secondary Metabolites and PI3K Inhibitory Activity of Colletotrichum gloeosporioides, a Fungal Endophyte of Uncaria rhynchophylla, Secondary Metabolites and PI3K Inhibitory Activity of Colletotrichum gloeosporioides, a Fungal Endophyte of Uncaria rhynchophylla, Secondary Metabolites and PI3K Inhibitory Activity of Colletotrichum gloeosporioides, a Fungal Endophyte of Uncaria rhynchophylla, Secondary Metabolites and PI3K Inhibitory Activity of Colletotrichum gloeosporioides, a Fungal Endophyte of Uncaria rhynchophylla[J]. Current Microbiology, Current Microbiology, Current Microbiology, Current Microbiology,2019, 2019, 2019, 2019,76, 76, 76, 76(7):904-908, 904-908, 904-908, 904-908.
APA	Yang ZD.(2019).Secondary Metabolites and PI3K Inhibitory Activity of Colletotrichum gloeosporioides, a Fungal Endophyte of Uncaria rhynchophylla.Current Microbiology,76(7),904-908.
MLA	Yang ZD."Secondary Metabolites and PI3K Inhibitory Activity of Colletotrichum gloeosporioides, a Fungal Endophyte of Uncaria rhynchophylla".Current Microbiology 76.7(2019):904-908.