Hypoglycaemic effect of comatin, an antidiabetic substance separated from Coprinus comatus broth, on alloxan-induced-diabetic rats

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	Hypoglycaemic effect of comatin, an antidiabetic substance separated from Coprinus comatus broth, on alloxan-induced-diabetic rats
	Ding, Zhongyang 1,2,3; Lu, Yingjian 1; Lu, Zhaoxin 1; Lv, Fengxia 1; Wang, Yuhong 2,3; Bie, Xiaomei 1; Wang, Feng 4; Zhang, Kechang 2,3
刊名	FOOD CHEMISTRY
	2010-07-01
卷号	121 期号:1 页码:39-43
关键词	Coprinus comatus 4 Non-enzymatic glycosylation Hypoglycaemic Alloxan 5-Dihydroxy-2-methoxy-benzaldehyde
ISSN号	0308-8146
通讯作者	Lu, ZX
英文摘要	Comatin, an inhibitor of the non-enzymatic glycosylation (NEG) reaction, was isolated from Coprinus comatus fermentation broth by macroporous resin separation, followed by chromatographic purification using a C18 reversed-phase column. The compound was identified as 4,5-dihydroxy-2-methoxy-benzal-dehyde by high-resolution MS, IR, NMR and UV analyses. The hypoglycaemic effect of comatin, on both normal and alloxan-induced-diabetic rats, was investigated in the paper. The blood glucose concentration of normal rats treated by the comatin at 80 mg/kg body weight was reduced from 5.14 mM to 4.28 mM in 3 h. Also, the concentrations of fructosamine, triglycerides and total cholesterol in induced-diabetic rats were significantly decreased. These results indicated that comatin could maintain a low level of blood glucose and improve glucose tolerance. (C) 2009 Elsevier Ltd. All rights reserved.
WOS标题词	Science & Technology ; Physical Sciences ; Life Sciences & Biomedicine
类目[WOS]	Chemistry, Applied ; Food Science & Technology ; Nutrition & Dietetics
研究领域[WOS]	Chemistry ; Food Science & Technology ; Nutrition & Dietetics
关键词[WOS]	IN-VITRO ; FRUITING BODIES ; GLYCATION ; MELLITUS ; INHIBITION ; MUSHROOM ; PRODUCTS ; EXTRACTS
收录类别	SCI
语种	英语
WOS记录号	WOS:000275360200005
公开日期	2013-11-15
内容类型	期刊论文
版本	出版稿
源URL	[http://ir.ipe.ac.cn/handle/122111/6122]
专题	过程工程研究所_生化工程国家重点实验室
作者单位	1.Nanjing Agr Univ, Sch Food Sci & Technol, Nanjing 210095, Peoples R China 2.Jiangnam Univ, Minist Educ, Key Lab Ind Biotechnol, Wuxi 214122, Peoples R China 3.Jiangnam Univ, Sch Biotechnol, Wuxi 214122, Peoples R China 4.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Ding, Zhongyang,Lu, Yingjian,Lu, Zhaoxin,et al. Hypoglycaemic effect of comatin, an antidiabetic substance separated from Coprinus comatus broth, on alloxan-induced-diabetic rats[J]. FOOD CHEMISTRY,2010,121(1):39-43.
APA	Ding, Zhongyang.,Lu, Yingjian.,Lu, Zhaoxin.,Lv, Fengxia.,Wang, Yuhong.,...&Zhang, Kechang.(2010).Hypoglycaemic effect of comatin, an antidiabetic substance separated from Coprinus comatus broth, on alloxan-induced-diabetic rats.FOOD CHEMISTRY,121(1),39-43.
MLA	Ding, Zhongyang,et al."Hypoglycaemic effect of comatin, an antidiabetic substance separated from Coprinus comatus broth, on alloxan-induced-diabetic rats".FOOD CHEMISTRY 121.1(2010):39-43.