Detecting the breakup of spiral waves in small-world networks of neurons due to channel block

doi:10.1007/s11434-012-5114-2

CORC > 兰州理工大学 > 兰州理工大学 > 理学院

	Detecting the breakup of spiral waves in small-world networks of neurons due to channel block
	Ma Jun 2,3; Huang Long 2; Ying HePing 1; Pu ZhongSheng 2
刊名	CHINESE SCIENCE BULLETIN
	2012-06
卷号	57 期号:17 页码:2094-2101
关键词	spiral wave factor of synchronization Hodgkin-Huxley neurons small-world networks channel block
ISSN号	1001-6538
DOI	10.1007/s11434-012-5114-2
英文摘要	The breakup of a spiral wave by blockade of sodium and potassium channels in a small-world network of Hodgkin-Huxley neurons is investigated in detail. The influence of ion channel block in poisoned excitable membrane patches of a certain size is measured, by varying channel noise and channel densities resulting from the change in conductance. For example, tetraethylammonium is known to cause a block (poisoning) of potassium channels, while tetrodotoxin blocks sodium channels. We observed the occurrence of spiral waves, which are ordered waves believed to play an important role in facilitating the propagation of electric signals across quiescent regions of the brain. In this paper, the effect of channel block was measured by the factors x (K) and x (Na), which represent the ratios of unblocked, or active, ion channels, to the overall number of potassium or sodium ion channels, respectively. To quantify these observations, we use a simple but robust synchronization measure, which succinctly captures the transition from spiral waves to other collective states, such as broken segments resulting from the breakup of the spiral wave. The critical thresholds of channel block can be inferred from the abrupt changes occurring in plots of the synchronization measure against different values of x (K) and x (Na). Notably, small synchronization factors can be tightly associated with states where the formation of spiral waves is robust to mild channel block.
资助项目	Natural Science Foundation of Lanzhou University of Technology[Q200706]
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	SCIENCE PRESS
WOS记录号	WOS:000304853100008
状态	已发表
内容类型	期刊论文
源URL	[http://119.78.100.223/handle/2XXMBERH/34903]
专题	理学院
通讯作者	Ma Jun
作者单位	1.Zhejiang Univ, Zhejiang Inst Modern Phys, Hangzhou 310027, Peoples R China 2.Lanzhou Univ Technol, Dept Phys, Lanzhou 730050, Peoples R China 3.Key Lab Gansu Adv Control Ind Proc, Lanzhou 730050, Peoples R China
推荐引用方式 GB/T 7714	Ma Jun,Huang Long,Ying HePing,et al. Detecting the breakup of spiral waves in small-world networks of neurons due to channel block[J]. CHINESE SCIENCE BULLETIN,2012,57(17):2094-2101.
APA	Ma Jun,Huang Long,Ying HePing,&Pu ZhongSheng.(2012).Detecting the breakup of spiral waves in small-world networks of neurons due to channel block.CHINESE SCIENCE BULLETIN,57(17),2094-2101.
MLA	Ma Jun,et al."Detecting the breakup of spiral waves in small-world networks of neurons due to channel block".CHINESE SCIENCE BULLETIN 57.17(2012):2094-2101.