TRANSITION OF ORDERED WAVES IN NEURONAL NETWORK INDUCED BY DIFFUSIVE POISONING OF ION CHANNELS

doi:10.1142/S0218339013500022

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	TRANSITION OF ORDERED WAVES IN NEURONAL NETWORK INDUCED BY DIFFUSIVE POISONING OF ION CHANNELS
	Huang, Long 1; Ma, Jun 1; Tang, Jun 2; Li, Fan 1
刊名	JOURNAL OF BIOLOGICAL SYSTEMS
	2013-03
卷号	21 期号:1
关键词	Spiral Wave Factor of Synchronization Breakup Channel Noise Line Defect
ISSN号	0218-3390
DOI	10.1142/S0218339013500022
英文摘要	Normal physiological activities are often affected by some drugs, and some ion channels are blocked due to the katogene of drugs. This paper investigates the propagation of ordered waves in neuronal networks induced by diffusive poisoning, where the process is measured by increasing the number of neurons in the poisoned area of the networks. A coefficient of poisoning K is defined to measure the time units from one poisoned site to the adjacent site, a smaller K means that more neurons are poisoned in a certain period (a higher poisoning speed). A statistical factor of synchronization R in the two-dimensional array is defined to detect the transition of spiral waves induced by ion channel blocking. It is confirmed that the evolution of the spiral waves depends on the coefficient of poisoning K and number of poisoned neurons. Furthermore, breakup of the spirals is observed when weak channel noise is considered. Finally, the formation of the spiral wave induced by blocking the target wave with line defects is briefly discussed.
资助项目	National Nature Science Foundation of China[11105219] ; National Nature Science Foundation of China[11265008]
WOS研究方向	Life Sciences & Biomedicine - Other Topics ; Mathematical & Computational Biology
语种	英语
出版者	WORLD SCIENTIFIC PUBL CO PTE LTD
WOS记录号	WOS:000317906200002
状态	已发表
内容类型	期刊论文
源URL	[http://119.78.100.223/handle/2XXMBERH/34739]
专题	理学院
通讯作者	Ma, Jun
作者单位	1.Lanzhou Univ Technol, Dept Phys, Lanzhou 730050, Peoples R China 2.China Univ Min & Technol, Coll Sci, Xuzhou 221000, Peoples R China
推荐引用方式 GB/T 7714	Huang, Long,Ma, Jun,Tang, Jun,et al. TRANSITION OF ORDERED WAVES IN NEURONAL NETWORK INDUCED BY DIFFUSIVE POISONING OF ION CHANNELS[J]. JOURNAL OF BIOLOGICAL SYSTEMS,2013,21(1).
APA	Huang, Long,Ma, Jun,Tang, Jun,&Li, Fan.(2013).TRANSITION OF ORDERED WAVES IN NEURONAL NETWORK INDUCED BY DIFFUSIVE POISONING OF ION CHANNELS.JOURNAL OF BIOLOGICAL SYSTEMS,21(1).
MLA	Huang, Long,et al."TRANSITION OF ORDERED WAVES IN NEURONAL NETWORK INDUCED BY DIFFUSIVE POISONING OF ION CHANNELS".JOURNAL OF BIOLOGICAL SYSTEMS 21.1(2013).