Isolation and Identification of New Impurities in Nomegestrol Acetate

	Isolation and Identification of New Impurities in Nomegestrol Acetate
	Yang Zhong-duo 2,4; Zhang Xu 2; Li Tao 2; Li Yuan-chao 1; Wang You-fu 3
刊名	CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
	2009-09-02
卷号	25 期号:5 页码:653-656
关键词	Steroid Nomegestrol acetate Estrane derivative
ISSN号	1005-9040
英文摘要	Three new and five known steroidal compounds as impurities in nomegestrol acetate(I) were isolated from the enriched mother liquor via various chromatographic methods. Their structures were elucidated by spectrometric analysis and single-crystal X-ray diffraction analysis. New compounds were characterized as 17 alpha-hydroxyl-3-oxoes-trane-5 beta,17-dicarbonitrile(1), 4-ethyl-17 alpha-hydroxyl-3-oxoestr-4-en-17-carbonitrile(2), 4-ethylestr-4-en-3,17-dione(3). The C-13 NMR data of known estrane derivatives(4-7) were also reported first time in this paper. The study may be helpful to identifing and characterizing all the impurities that are present at a level of 0.1% and be useful in the quality control of the production of nomegestrol acetate.
WOS研究方向	Chemistry
语种	英语
出版者	HIGHER EDUCATION PRESS
WOS记录号	WOS:000271081900013
内容类型	期刊论文
源URL	[http://ir.lut.edu.cn/handle/2XXMBERH/155565]
专题	生命科学与工程学院机电工程学院
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China; 2.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730050, Peoples R China; 3.Xianju Pharmaceut Factory, Branch Factory 2, Xianju 317300, Peoples R China; 4.Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
推荐引用方式 GB/T 7714	Yang Zhong-duo,Zhang Xu,Li Tao,et al. Isolation and Identification of New Impurities in Nomegestrol Acetate[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2009,25(5):653-656.
APA	Yang Zhong-duo,Zhang Xu,Li Tao,Li Yuan-chao,&Wang You-fu.(2009).Isolation and Identification of New Impurities in Nomegestrol Acetate.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,25(5),653-656.
MLA	Yang Zhong-duo,et al."Isolation and Identification of New Impurities in Nomegestrol Acetate".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 25.5(2009):653-656.