Heparin-like macromolecules for the modification of anticoagulant biomaterials

doi:10.1002/mabi.201100249

CORC > 兰州理工大学 > 兰州理工大学 > 省部共建有色金属先进加工与再利用国家重点实验室

	Heparin-like macromolecules for the modification of anticoagulant biomaterials
	Ran, Fen 1,2,3; Nie, Shengqiang 1,3; Li, Jie 2; Su, Baihai 1,3; Sun, Shudong 1,3; Zhao, Changsheng 1,3
刊名	Macromolecular Bioscience
	2012
卷号	12 期号:1 页码:116-125
关键词	Artificial organs Biocompatibility Living polymerization Macromolecules Phase separation Polysaccharides Anticoagulant properties Bioartificial liver Blood compatibility Coagulation factor Flat sheet membranes Liquid-liquid phase separation Polyethersulfone membrane RAft polymerization
ISSN号	16165187
DOI	10.1002/mabi.201100249
英文摘要	A heparin-like structured macromolecule (HLSM) is synthesized by RAFT polymerization using carboxyl-terminated trithiocarbonate as the RAFT agent. The HLSM can be directly blended with PES in DMAC to prepare flat-sheet membrane by means of a liquid-liquid phase separation technique. The synthesized polymeric material retard blood clotting and the modified membrane exhibits good anticoagulant ability due to the existence of the important functional groups -SO3H, -COOH and -OH. The anionic groups on the membrane surface may bind coagulation factors and thus improve anticoagulant ability. The results indicate that the HLSM has potential to improve the anticoagulant properties of biomaterials and to be applied in blood purification including hemodialysis and bioartificial liver supports. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
资助项目	National Natural Science Foundation of China[50973070] ; National Natural Science Foundation of China[51073105] ; National Natural Science Foundation of China[30900691]
WOS研究方向	Biochemistry & Molecular Biology ; Materials Science ; Polymer Science
语种	英语
出版者	Wiley-VCH Verlag
WOS记录号	WOS:000298843000014
状态	已发表
内容类型	期刊论文
源URL	[http://ir.lut.edu.cn/handle/2XXMBERH/111402]
专题	省部共建有色金属先进加工与再利用国家重点实验室材料科学与工程学院
通讯作者	Sun, Shudong
作者单位	1.Sichuan Univ, Coll Polymer Sci & Engn, State Key Lab Polymer Mat Engn, Chengdu 610065, Peoples R China 2.Lanzhou Univ Technol, State Key Lab Gansu Adv Nonferrous Met Mat, Lanzhou 730050, Peoples R China 3.Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R China
推荐引用方式 GB/T 7714	Ran, Fen,Nie, Shengqiang,Li, Jie,et al. Heparin-like macromolecules for the modification of anticoagulant biomaterials[J]. Macromolecular Bioscience,2012,12(1):116-125.
APA	Ran, Fen,Nie, Shengqiang,Li, Jie,Su, Baihai,Sun, Shudong,&Zhao, Changsheng.(2012).Heparin-like macromolecules for the modification of anticoagulant biomaterials.Macromolecular Bioscience,12(1),116-125.
MLA	Ran, Fen,et al."Heparin-like macromolecules for the modification of anticoagulant biomaterials".Macromolecular Bioscience 12.1(2012):116-125.