Biocompatibility of modified polyethersulfone membranes by blending an amphiphilic triblock co-polymer of poly(vinyl pyrrolidone)-b-poly(methyl methacrylate)-b-poly(vinyl pyrrolidone)

doi:10.1016/j.actbio.2011.05.026

	Biocompatibility of modified polyethersulfone membranes by blending an amphiphilic triblock co-polymer of poly(vinyl pyrrolidone)-b-poly(methyl methacrylate)-b-poly(vinyl pyrrolidone)
	Ran, Fen 1,2,3; Nie, Shengqiang 1,2; Zhao, Weifeng 1,2; Li, Jie 3; Su, Baihai 1; Sun, Shudong 1; Zhao, Changsheng 1,2
刊名	ACTA BIOMATERIALIA
	2011-09
卷号	7 期号:9 页码:3370-3381
关键词	Polyethersulfone membrane Amphiphilic triblock co-polymer Ultrafiltration Blood compatibility Cytocompatibility
ISSN号	1742-7061
DOI	10.1016/j.actbio.2011.05.026
英文摘要	An amphiphilic triblock co-polymer of poly(vinyl pyrrolidone)-b-poly(methyl methacrylate)-b-poly(vinyl pyrrolidone) (PVP-b-PMMA-b-PVP) was synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. The block co-polymer can be directly blended with polyethersulfone (PES) using dimethylacetamide (DMAC) as the solvent to prepare flat sheet and hollow fiber membranes using a liquid-liquid phase separation technique. The PVP block formed a brush on the surface of the blended membrane, while the PMMA block mingled with the PES macromolecules, which endowed the membrane with permanent hydrophilicity. After adding the as-prepared block co-polymer the modified membranes showed lower protein (bovine serum albumin) adsorption, suppressed platelet adhesion, and a prolonged blood coagulation time, and thereby the blood compatibility was improved. Furthermore, the modified PES membranes showed good cytocompatibility, ultrafiltration and protein anti-fouling properties. These results suggest that surface modification of PES membranes by blending with the amphiphilic triblock co-polymer PVP-b-PMMA-b-PVP allows practical application of these membranes with good biocompatibility in the field of blood purification, such as hemodialysis and bio-artificial liver support. (C) 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
资助项目	Sichuan Youth Science and Technology Foundation[08ZQ026-038]
WOS研究方向	Engineering ; Materials Science
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000294040900014
状态	已发表
内容类型	期刊论文
源URL	[http://119.78.100.223/handle/2XXMBERH/35058]
专题	材料科学与工程学院省部共建有色金属先进加工与再利用国家重点实验室
通讯作者	Zhao, Changsheng
作者单位	1.Sichuan Univ, Coll Polymer Sci & Engn, State Key Lab Polymer Mat Engn, Chengdu 610065, Peoples R China 2.Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610065, Peoples R China 3.Lanzhou Univ Technol, State Key Lab Gansu Adv Nonferrous Met Mat, Lanzhou 730050, Peoples R China
推荐引用方式 GB/T 7714	Ran, Fen,Nie, Shengqiang,Zhao, Weifeng,et al. Biocompatibility of modified polyethersulfone membranes by blending an amphiphilic triblock co-polymer of poly(vinyl pyrrolidone)-b-poly(methyl methacrylate)-b-poly(vinyl pyrrolidone)[J]. ACTA BIOMATERIALIA,2011,7(9):3370-3381.
APA	Ran, Fen.,Nie, Shengqiang.,Zhao, Weifeng.,Li, Jie.,Su, Baihai.,...&Zhao, Changsheng.(2011).Biocompatibility of modified polyethersulfone membranes by blending an amphiphilic triblock co-polymer of poly(vinyl pyrrolidone)-b-poly(methyl methacrylate)-b-poly(vinyl pyrrolidone).ACTA BIOMATERIALIA,7(9),3370-3381.
MLA	Ran, Fen,et al."Biocompatibility of modified polyethersulfone membranes by blending an amphiphilic triblock co-polymer of poly(vinyl pyrrolidone)-b-poly(methyl methacrylate)-b-poly(vinyl pyrrolidone)".ACTA BIOMATERIALIA 7.9(2011):3370-3381.